脳血管障害患者における下垂体前葉ホルモン分泌能の検討 : 高血圧性脳内出血症例について

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Systematic anterior pituitary function tests were performed in 49 patients with hypertensive intracranial hematoma, and the results were assessed for correlation with various clinical factors. The subjects were 18 patients with putaminal hemorrhage, 21 with thalamic hemorrhage, 6 with subcortical hemorrhage, and 3 with cerebellar hemorrhage. In the radio-immunoassay, growth hormone and cortisol were determined during the insulin tolerance test (regular insulin, 0.15-0.20 U/kg), luteinizing hormone and follicle stimulating hormone under luteinizing hormone-releasing hormone (100 μg), thyroid stimulating hormone and prolactin under thyrotropin-releasing hormone (500 μg). The impaired rate was calculated for each patient as the number of impaired anterior pituitary hormone secretions divided by the number of effectively examined anterior pituitary hormones. The data were assessed statistically by analysing the variance due to age, sex, clinical symptoms, disease stage at the test time, complications, and location of the hematoma, and the impaired rate. The results were as follows. 1) Growth hormone, thyroid stimulating hormone, prolactin, cortisol, follicle stimulating hormone, and luteinizing hormone secretions were impaired in 47%, 45%, 29%, 22%, 22%, and 20% of the cases, respectively. 2) The case incidence of impaired anterior pituitary hormonal secretion was 86%, but its intensity was mild in most of the patients. 3) The impaired rate was significantly higher in patients with consciousness disturbance and hidrocephalus. 4) The impaired rate was higher in large hematoma patients in the putaminal and thalamic hemorrhage groups.
日本脳神経外科学会の論文
1985-06-15

脳血管障害患者における下垂体前葉ホルモン分泌能の検討 : 高血圧性脳内出血症例について

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