The Effectiveness of Combination Therapy with Hu IFN-β and ACNU against Malignant Glioma
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概要
- 論文の詳細を見る
Combination therapy with human fibroblast interferon (Hu IFN-β) and 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) was administered against a cell line of human malignant glioma transplanted into nude mice, and the histological changes were examined. The mice were divided into four groups (control, Hu IFN-P, ACNU, and combination therapy). The drugs were administered intraperitoneally. As in an earlier in vitro study, the anti-proliferative effect in the combination therapy group was significantly greater than that in the other groups. In the combination therapy group the histological findings also revealed more degenerative changes, such as a tendency for tumor cells to separate from each other, an increase in multinucleate giant cells, and extensive necrosis. As an adjunct to surgery, combination therapy with Hu IFN-P and ACNU may be a significantly effective treatment for malignant gliomas.
- 日本脳神経外科学会の論文
- 1987-01-15
著者
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Yoshida Jun
Department Of Neurosurgery Nagoya University Graduate School Of Medicine
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KAGEYAMA Naoki
Department of Neurosurgery, Nagoya University school of Medicine
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Yoshida J
Department Of Neurosurgery Nagoya University School Of Medicine
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Kageyama N
Department Of Neurosurgery Nagoya University School Of Medicine
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Kageyama Naoki
Department Of Neurosurgery Kishiwada City Hospital
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ENOMOTO Hitomi
Department of Neurosurgery, Nagoya University, School of Medicine
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Enomoto Hitomi
Department Of Neurosurgery Nagoya University School Of Medicine
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Yoshida Jun
Department Of Basic Science Graduate School Of Arts And Sciences The University Of Tokyo
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YOSHIDA Jun
Department of Neurosurgery, Nagoya University, School of Medicine
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