Tumor-specific Binding of Radiolabeled G-22 Monoclonal Antibody in Glioma Patients
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概要
- 論文の詳細を見る
Iodine-131-labeled G-22 monoclonal antibody F (ab')_2 fragment reacting specifically with a glioma-as-sociated surface glycoprotein was administered to 12 glioma patients to investigate its use in radioimaging of intracranial gliomas. No immediate or delayed side effects were attributable to antibody injection. Nine patients received the radiolabeled complex intravenously. The images of low-grade gliomas were generally poor and disappeared within 4 days. High-contrast images were obtained beyond the 7th day in high-grade gliomas except one case in the pineal region. Three patients received intraventricular or intratumoral administration. Clear images of all tumors were demonstrated from the 2nd until later than the 7th day. One patient with cerebrospinal fluid (CSF) dissemination of brainstem glioma demonstrated negative CSF cytology after intraventricular administration.
- 日本脳神経外科学会の論文
- 1992-03-15
著者
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若林 俊彦
名古屋大学大学院医学系研究科 脳神経病態制御学
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Mizuno Masaaki
名古屋大学 医学系研究科循環器内科
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Mizuno M
Nagoya Univ. Graduate School Of Medicine Nagoya Jpn
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Mizuno M
Research Center Mitsubishi Kasei Corporation
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Mizuno Masaaki
Department Of Neurosurgery Nagoya University School Of Medicine
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Yoshida Jun
Department Of Neurosurgery Nagoya University Graduate School Of Medicine
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Seo Hisao
Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya Uni
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Seo Hisao
名古屋大学環境医学研究所
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Seo H
Nagoya Univ. Nagoya Jpn
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Wakabayashi Toshihiko
Department of Neurosurgery, Nagoya University Graduate School of Medicine
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SUGITA Kenichiro
Department of Neurosurgery,Nagoya University School of Medicine
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OSHIMA Motoo
Radiology, Nagoya University School of Medicine
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TADOKORO Masanori
Radiology, Nagoya University School of Medicine
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SAKUMA Sadayuki
Radiology, Nagoya University School of Medicine
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Seo Hisao
Department Of Endocrinology And Metabolism Division Of Molecular And Cellular Adaptation Research In
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Seo Hisao
Research Institute Of Environmental Medicine Nagoya University
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Seo Hisao
Department Of Endocrinology And Metabolism The Research Institute Of Environmental Medicine Nagoya U
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Oshima Motoo
Radiology Nagoya University School Of Medicine
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Seo H
Department Of Endocrinology And Metabolism Division Of Molecular And Cellular Adaptation Institution
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Sakuma Sadayuki
Radiology Nagoya University School Of Medicine
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Wakabayashi T
Department Of Neurosurgery Nagoya Central Hospital
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Wakabayashi Toshihiko
Department Of Neurosurgery Nagoya University Graduate School Of Medicine
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Sugita K
Yamanashi Medical Univ. Yamanashi
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Sugita Kenichiro
Department Of Neurosurgery Nagoya University School Of Medicine
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Tadokoro Masanori
Radiology Nagoya University School Of Medicine
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Mizuno Masaaki
Department Of Neurosurgery Nagoya University School Of Medicme
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Mizuno Masaaki
Department Of Chemistry Faculty Of Engineering Science Osaka University
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Wakabayashi Toshihiko
Department Of Neurosurgery Graduate School Of Medicine Nagoya University
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Yoshida Jun
Department Of Basic Science Graduate School Of Arts And Sciences The University Of Tokyo
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Mizuno Masaaki
Department of Molecular Neurosurgery, Nagoya University Graduate School of Medicine
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SEO Hisao
Department of Biomedical Science, College of Life and Health Sciences, Chubu University
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