Growth Inhibition of Glioma Cells by Liposome-mediated Cell Transfection with Tumor Necrosis Factor-α Gene : Its Enhancement by Prior γ-interferon Treatment
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概要
- 論文の詳細を見る
A new approach to the treatment of malignant glioma is cytokine gene therapy to produce growth inhibitors in cells.Previously,we showed that human glioma cells selectively transfected with the gene of interferon(IFN)-β and/or IFN-γ by our novel liposomes tagged with monoclonal antibody against a glioma-associated antigen achieved a remarkable growth inhibition effect.In the present experiment,we demonstrated the effectiveness of gene therapy against glioma cells using liposomes bearing a plasmid containing the gene for tumor necrosis factor(TNF)-α.We also found that the effect of endogenous TNF-α was enhanced by treatment of IFN-γ prior to the transfection with the TNF-α gene.
- 日本脳神経外科学会の論文
- 1992-11-15
著者
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OYAMA Hirofumi
Department of Neurosurgery, Ogaki Municipal Hospital
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Mizuno Masaaki
名古屋大学 医学系研究科循環器内科
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Mizuno M
Nagoya Univ. Graduate School Of Medicine Nagoya Jpn
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Mizuno M
Research Center Mitsubishi Kasei Corporation
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Mizuno Masaaki
Department Of Neurosurgery Nagoya University School Of Medicine
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Yoshida Jun
Department Of Neurosurgery Nagoya University Graduate School Of Medicine
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SUGITA Kenichiro
Department of Neurosurgery,Nagoya University School of Medicine
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Oyama Hirofumi
Department Of Human Welfare Ritsumeikan University
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Oyama Hirofumi
Department Of Neurosurgery Nagoya University School Of Medicine
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Sugita K
Yamanashi Medical Univ. Yamanashi
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Sugita Kenichiro
Department Of Neurosurgery Nagoya University School Of Medicine
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Mizuno Masaaki
Department Of Neurosurgery Nagoya University School Of Medicme
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Mizuno Masaaki
Department Of Chemistry Faculty Of Engineering Science Osaka University
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Yoshida Jun
Department Of Basic Science Graduate School Of Arts And Sciences The University Of Tokyo
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Mizuno Masaaki
Department of Molecular Neurosurgery, Nagoya University Graduate School of Medicine
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