Preoperative Short-term Administration of Octreotide for Facilitating Transsphenoidal Removal of Invasive Growth Hormone-secreting Macroadenomas
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概要
- 論文の詳細を見る
鞍上部と一側海綿静脈洞内に進展したGH産生下垂体腺腫の3症例にoctreotied (100μg×2回/日)を2週間投与し、軽蝶形骨洞手術を行った。術前GH値は82,148,129から22,12,9ng/mlに各々低下し、2症例では鞍上進展が消失し腫瘍サイズは約50%に縮小した。鞍上進展の消失により、腫瘍本体は正常下垂体から鋭的に剥離摘出された。術後MRIで海綿静脈洞内残存腫瘍が疑われたが、GH値はbromocriptine内服中の2症例で2ng/ml以下、他1症例では5以下に低下している。octreotide術前投与で腫瘍が縮小すれば、鞍内の正常下垂体温存と腫瘍摘出が完全となり、海綿静脈洞内残存腫瘍には正常下垂体に照射することなくガンマナイフ治療も可能である。
- 日本脳神経外科学会の論文
- 1999-07-15
著者
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Yoshida Jun
Department Of Neurosurgery Nagoya University Graduate School Of Medicine
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立花 栄二
名古屋大学脳神経外科
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Saito Kiyoshi
Department Of Neurosurgery Nagoya University Graduate School Of Medicine
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Yoshida Jun
Department Of Basic Science Graduate School Of Arts And Sciences The University Of Tokyo
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Saito Kiyoshi
Department Of Mech. Engineering Waseda University
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Saito Kiyoshi
Department Of Neurosurgery Nagoya University School Of Medicine
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Saito Kiyoshi
Department Of Materials Science And Technology Faculty Of Engineering Toin University Of Yokohama
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Saito Kiyoshi
Department of Chemistry, University of Tsukuba
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