Vasodilatory Effect of Basic Fibroblast Growth Factor in Isolated Rat Cerebral Arterioles : Mechanisms Involving Nitric Oxide and Membrane Hyperpolarization
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概要
- 論文の詳細を見る
Basic fibroblast growth factor (bFGF), a potent mitogen, acutely dilates cerebral blood vessels and may be effective in reducing cerebral infarction. However, the vasodilatory mechanism, which may involve nitric oxide (NO), is not completely understood. This study investigated whether membrane hyperpolarization is also involved in this mechanism. Membrane potential (MP) of smooth muscle cells and vessel diameter of isolated intracerebral arterioles were simultaneously measured following extraluminal application of bFGF in rats. The involvement of NO and adenosine triphosphate-sensitive potassium (K_<ATP>) channels in bFGF-induced vasodilation and membrane hyperpolarization was evaluated usiug specific inhibitors, N^G-monomethyl-L-arginine (L-NMMA, 10^<-4>M) and glibenclamide (GB, 10^<-5>M), respectively. The resting MP was recorded at a mean value of -31.9 : 4.5 mV. bFGF (1 to 1000 ng/ml) produced significant vasodilation and hyperpolarization. Treatment with L-NMMA caused vasoconstriction and significantly attenuated bFGF-induced vasodilation without affecting membrane hyper-polarization. In the presence of GB, the membrane potential was significantly depolarized but the vessel diameter was only marginally reduced, so bFGF-induced membrane hyperpolarization was inhibited while arteriolar dilation was attenuated. These results suggest that bFGF-induced vasodilation is mediated by a mechanism involving both NO and membrane hyperpolarization, and that membrane hyperpolarization is caused by the activation of KATP channels.
- 日本脳神経外科学会の論文
- 2001-04-15
著者
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Yoshida Jun
Department Of Neurosurgery Nagoya University Graduate School Of Medicine
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Kajita Yasukazu
Department of Neurosurgery, Nagoya University Graduate School of Medicine
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TAKAYASU Masakazu
Department of Neurosurgery, Okazaki Municipal Hospital
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Takayasu Masakazu
Department Of Neurosurgery Okazaki Municipal Hospital
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Takayasu Masakazu
Department Of Neurosurgery Nagoya University School Of Medicine
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Kajita Yasukazu
Department Of Neurosurgery Nagoya University Graduate School Of Medicine
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Yoshida Jun
Department Of Neurosurgery Nagoya University School Of Medicine
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DIETRICH Hans
Department of Neurosurgery, Washington University School of Medicine
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DACEY Jr
Department of Neurosurgery, Washington University School of Medicine
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Dacey Jr
Department Of Neurosurgery Washington University School Of Medicine
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Dietrich Hans
Department Of Neurosurgery Washington University School Of Medicine
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Yoshida Jun
Department Of Basic Science Graduate School Of Arts And Sciences The University Of Tokyo
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Takayasu Masakazu
Department Of Neurosurgery Aichi Medical University
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Yoshida Jun
Departments Of Neurosurgery And Radiology Nagoya University School Of Medicine
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Takayasu Masakazu
Department Of Neurological Surgery Aichi Medical University
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