トコンシロップの品質評価及びその催吐剤としての臨床効果

概要

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In our hospital we prepared ipecac syrup from various lots of powdered ipecac available on the market, and we made an alkaloid assay of ipecac using HPLC method. Total ether-soluble alkaloids of the lots of powdered ipecac were in conformity with the regulation by JP XI. However, the ratio of emetine to cephaeline, which affects the vomiting action, was found to be different for each lot of powdered ipecac. Ipecac alkaloid assay using HPLC was simple to perform, in comparison with the USP method: the HPLC method requires no extraction. At our hospital, 90% of 71 pediatric patients who had mistakenly ingested a dangerous substance, were clinically treated with ipecac syrup. Incidence of accidental ingestion of substances among young children is so high that the regulation of the content of emetine and cephaeline in powdered ipecac seems to be required.
日本医療薬学会の論文
1989-02-20