ヒスチジン銅注射液の安定性

概要

論文の詳細を見る
The solution stability of copper histidinate, which has been used in place of copper acetate or copper sulfate as an intravenous injection for copper supplement treatment of Menkes disease, has been studied. The solutions with various pH's were prepared and their spectral change was monitored by means of UV-visible spectrometer. Although spectral change was very small in acidic and neutral solutions at 5℃, a large decrease in the absorption peak at 630 nm was observed in the basic solution. Change in the copper concentration was quantitatively analyzed by both UV-visible and ICP-MS spectroscopic techniques. Based on these results, the neutral and acidic copper histidinate solutions were concluded to be stable at least for a month if they are stored at 5℃.
日本医療薬学会の論文
1994-02-20