高分子物質を含むリファンピシンゲル軟膏からのリファンピシンの放出特性

概要

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Rifampicin(RFP) gels were prepared by using polymer, surfactant and water, and their pharmaceutical characteristics were evaluated. Sodium polyacrylate (PAA-Na) and sodium carboxymethyl cellulose (CMC-Na) were used as polymers, and polysorbate 80 (Tween 80) and hydrogenated castor oil-polyoxyethylene castor oil (HCO-60) were used as surfactants. The release of RFP from the gel was measured through a cellulose membrane (Millipore Co.) using a dissolution test instrument (Toyama Sangyo Co.). Furthermore, the gel's characteristics in viscosity were evaluated with a viscometer, The following results were obtained: 1. As the viscosity of the gel base is increased, the release of RFP from the gel base decreases. 2. The RFP release rate from gel base containing PAA-Na was higher than that containing CMC-Na. 3. No significant effect of surfactant concentration on the release of RFP from the gel base was found. 4. The pharmaceutical design of RFP gel including a polymer may be possible by further studies of stability, rheology and bioavailability.
日本医療薬学会の論文
1987-10-20