ポリグリセリン脂肪酸エステルを用いたリファンピシンゲル状軟膏の物理化学的性状

概要

論文の詳細を見る
Rifampicin (RFP) gels were prepared with a new gel base consisting of polyglycerol ester (PGE), glycerin and oil. PGE used was decaglycerol ester (DGE) that was a monoester compound of decaglycerin and one of either lauric acid, myristic acid, stearic acid or oleic acid. Oils used were liquid paraffin, isopropyl myristate, isostearyl palmitate, octyl dodecanol and glycerin tri 2-ethyl hexanoate. 24 kinds of RFP gels were obtained by combination of these DGE and oil. These RFP gels were compared for their physico-chemical properties of stability, viscosity, hardness and dissolution rate. The results were as follows: 1. The preparation of RFP gel using a DGE gel base was affected by the kind of DGE and oils used. It was also affected by addition of propylene glycol. 2. The stability of RFP gel was affected by the kind of DGE and oils used and by the addition of propylene glycol. 3. The combination of DGE and liquid paraffin, or glycerin tri 2-ethyl hexanoate was more stable than others. 4. It was predicted that a concentration range of the optimum stable combination of DGE, oil and other additives existed in all RFP gels. 5. It can be assumed that these RFP gels possess the properties of ointment.
日本医療薬学会の論文
1988-06-20