サイログロブリンおよびその合成ペプチド抗原に対するバセドウ病患者T細胞の反応性

概要

論文の詳細を見る
Graves' disease is a common organ specific disorder characterized by immune response toward a number of thyroid proteins including thyroglobulin (Tg) , thyroid peroxidase (TPO) , and TSH receptor. Although considerable progress has been made in understanding and mapping the response of autoantibodies to Tg, much less is known about recognition of Tg by pathogenic T-cell in human diseases. To identify such reactions, we analyzed the proliferative responses of T-cells in the peripheral blood (PBMC) to Tg and to synthetic peptides. Nineteen patients with Graves' disease, 2 patients with chronic thyroiditis , and　5 normal subjects were studied. PBMC from 4 of the patients with Graves' disease reacted to Tg. Their reactivities to synthetic peptides were less than that to Tg. This may lead to a design of more accurate and specific diagnostic assays for the cellular immunity to the thyroid antigens in autoimmune thyroid disorders as well as to the development of specific immunotherapy for the disorders.
信州大学の論文