レクチン阻害サイログロブリン測定による新しい甲状腺乳頭癌診断法の開発

概要

論文の詳細を見る
The aim of this study was to differentiate thyroid papillary carcinoma from benign thyroid tumors. We have developed new monoclonal antibodies that can specifically recognize epitopes on thyroglobulin(Tg). Using the monoclonal antibodies, an ELISA system was established to identify, patients with thyroid cancer by measuring tissue levels of Tg. Our previous observation indicated that the sugar chains of Tg associated with thyroid cancer react with lectins differently from that of normal Tg. We then investigated the ratios of unbound Tg { Lectin Inhibitory Tg(%)} in various thyroid tissues by ELISA using LCA lectin. The Lectin Inhibitory Tg in papillary carcinoma was significantly higher than that observed in benign follicular adenoma. This result clearly indicates that the monoclonal antibody-based ELISA would significantly contribute to the diagnosis of patients with thyroid papillary carcinoma.
香川県立保健医療大学の論文
2004-03-31