<論文>有機溶媒中でのPseudomonas cepaciaリパーゼを用いた酢酸 : イソプロペニルとエステル交換による2-オクタノールの動力学的分割

概要

論文の詳細を見る
Pseudomonas cepacia lipase (PCL) catalyzed transesterification between isopropenyl acetate (1) and 2-octanol (2) has been studied using a variery of organic solvents. The kinetic data from the racemic alcohol (RS)-(2) did not fit the homocompetitive equation of the kinetic resolution theory : the enantiomeric ratio (E value) was not constant and had a maximumn agaist the extent of conversion (c). The (S) isomer with high optical purity (ee>98%) was resolved from (RS)-(2), however, (R) one (ee>95%) did not obtained even at low conversion because of low enanntioselectivity. The resolution of (R) isomer from (R)-rich-(2) was attemped : the optical purities of the resolutants were accordance with those calculated from the proposed format using the kinetic resolution data of (RS)-(2). From the above observations, it was shown that secondary alcohol with high optical purity was able to be resolved by PCL catalyzed transesterification with (1).
北海道東海大学の論文
2000-03-25