<原著>OK432およびthymosinの腫瘍免疫に対する影響

概要

論文の詳細を見る
In order to elucidate immunopotentiating ability and the immunologic mechanism of immunopotentiator, effects of OK 432 and thymosin on the killer T cell or the suppressor T cell have been examined in the spleen cells of normal C_3H/He mice and syngeneic transplanted tumor bearing mice. A group of normal mice was given either 5 KE/kg of OK 432 every day or 1 mg of thymosin (fraction IV) intraperitoneally every other day and sacrificed on the eighth day. Tumor bearing mice were given the same treatment procedure of OK 432 or thymosin from the day of tumor transplantation and were sacrificed on the twentieth day. Results were as follows : 1)^3H-TdR uptake and the cytotoxic activity of spleen cells after MLTC increased in OK 432 treated normal mice as compared with untreated control mice. Thymosin treated normal mice, however, showed no increase. 2) The response of spleen cells to mitogen (PHA and Con A) was impaired in tumor bearing mice as compared with normal mice, and OK 432 treatment brought the response up to the same level as control mice ; however, thymosin treated tumor mice did not show improvement. 3) Hyperactivity of suppressor cells was demonstrated in untreated tumor bearing mice and was improved by the treatment with OK 432. Thymosin, though, had no effect. These observations indicate that OK 432 appears to be more effective than thymosin as an immunopotentiator in tumor bearing mice.
近畿大学の論文
1979-06-25