<原著>血液透析症例の口渇とrenin-angiotensin-aldosterone系

概要

論文の詳細を見る
In order to clarify the cause of thirst, renin-angiotensin-aldosterone system, antidiuretic hormone (ADH) and solutes constituting plasma osmotic pressure were measured in 58 patients undergoing maintenance hemodialysis. The level of angiotensin II (Ang II) was high in 44 patients (76%) and three times higher than the normal level in 17 patients (29%). Eleven (65%) of the 17 patients complained of severe thirst. The blood levels of ADH and solutes constituting plasma osmotic pressure were not correlated with the degree of thirst. The 17 patients were given 25 to 50 mg/day of captopril. In six of the 11 patients showing abnormally high Ang II levels with severe thirst, the level of Ang II dropped toward the normal level and thirst tended to be improved. The present study suggests that in addition to the thirst due to volume receptors and osmotic receptors, thirst caused by direct actions of Ang II on the thirst center exists in patients undergoing maintenance hemodialysis.
近畿大学の論文
1986-03-25