<原著>骨髄性白血病細胞に特異的に発現する遺伝子の検出

概要

論文の詳細を見る
Poly(A)-mRNAs obtained from normal bone marrow and peripheral blood mononuclear cells were subtracted from labeled c-DNA of HL-60 cells in which granulocytic differentiation had been induced with dimethyl sulfoxide. One c-DNA clone was thus isolated. The corresponding m-RNA was expressed in myelocytic leukemia cell lines and leukemia cells were obtained from patients with acute myelocytic leukemia. However, the gene was not expressed in lymphocytic malignancy cell lines or normal blood cells. Therefore, expression of this gene may be utilized as a specific marker for myelocytic leukemia cells. Stable expression of the gene was maintained throughout all stages of HL-60 differentiation. This gene may prove to be valuable in the detection of residual leukemia cells after chemotherapy.
近畿大学の論文
1991-09-25