<症例>良性M蛋白血症を伴った急性骨髄性白血病の一例

概要

論文の詳細を見る
The patient reported here is a very rare case which shows simultaneous occurrence of acute myeloblastic leukemia and benign monoclonal gammopathy without prior chemotherapy and irradiation. A 42-year-old man was admitted to the Kinki University Hospital because of general fatigue and fever. Peripheral blood examination was disclosed as follows : Hb 9.1g/dl, Ht 27.6%, platelet count 19.9×10^4/μl and white blood cell count 27,400,including 90% atypical blast cells which showed myeloid markers (peroxidase(+), Sudan(+), esterase(-) and Auer bodv(+)). In bone marrow, similar atypical myeloblast cells reached 83.3% and 2.5% of plasma cells which showed no morphological abnormality. Total serum protein was 7.5g/dl and M-component was observed in γ gl. area being identified as IgG of L type by immunoelectrophoresis. Serum IgG level increased 2.45g/dl and Bence-Jones protein was demonstrated in the urine. Serum IgA and IgM levels were within normal range and no evidence of punched out lesion on bone X ray films was observed. On the basis of these findings, the diagnosis of acute myeloblastic leukemia (M1 type of FAB classification) with benign monoclonal sammopathy was made.
近畿大学の論文
1984-12-30