<基礎的研究発生病理>SHRSP脳組織中のプラスミノーゲン・アクチベータ・インヒビターについて

概要

論文の詳細を見る
Plasminogen activator inhibitors (PAIs) were partially purified from the brain tissue of spontaneously hypertensive rat-stroke prone (SHRSP) and that of Wistar-Kyoto rat (WKY), using salting-out, acidification, diethylaminoethyl (DEAE) cellulose column and anti-PAI IgG Sepharose column. Though the partially purified material showed two bands with molecular weights of 67 kDa and 40kDa in sodium dodecyl sulfate polyacrylamide get electrophoresis (SDS-PAGE), PAI activity was found in the band with molecular weight of 40kDa by reverse fibrin autography. Specific activities of PAI in SHRSP and WKY were 59.6U/A_<280> and 339.1 U/A_<280>, respectively. PAI activity in WKY was higher compared with that in SHRSP, which may be one of the factors for the stroke.
近畿大学の論文
1988-12-30