<症例>成人型T細胞性白血病の1剖検例 : 白血病細胞の免疫学的所見

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A 56-year-old man was admitted to the Kinki University hospital because of dyspnea and abdominal pain. The physical examination revealed the decreasing breath-sound and peripheral edema, but the liver and spleen were not palpable because of ascites. The skin eruption was seen on the right chest, the axillaer and right upper arm. Lymphadenopathy was seen systemically. The hematocrit was 42.5%, the white cell count was 24.9×10^4/mm^3 with 93% lymphocytes (leukemic cells) which had deeply lobulated nuclei. The platelet count was 14.4×10^4. The leukemic cells from the patient carried the receptor for sheep erythrocytes. Surface immunoglobulin was not detected. Terminal deoxinucleotidyl transferase activity was 1.2 u and Ia like antigen was positive. The leukemic cells from the patient could be neither responder nor stimulator in one-way mixed lymphocyte culture. PHA response was low. Suppressor function was found in in-vitro immunoglobulin synthesis stimulated with PWM. Predonisolone and vincristin were administered under the diagnosis of adult T cell leukemia without success. He died of the generalized aspergillus infection. Autopsy findings were as follows : 1) Lymphocytic leukemia 2) lymphnodes swelling : hilus, mesenterium and inguinale 3) aspergillus infection : the lung, heart and kidney 4) hepatosplenomegaly : liver 1,330 gr, spleen 210 gr.
近畿大学の論文
1981-03-25