<原著>Neurotropin^[○!R]のヌードマウス自己赤血球ロゼット形成脾細胞に及ぼす影響

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A subpopulation of mouse thymus and spleen lymphocytes can bind with autologous erythrocytes forming rosettes. The number of this autologous rosette-forming cells (ARFC) is abnormally high in the spleens of nude mice and it is suggested that ARFC might belong to immature T-cell precursors. This paper describes the effect of Neurotropi^[○!R] (NSP) on the number of ARFC and Thy-1 positive cells in the spleens of nude mice. Control none treated nude mice showed that ARFC was 227±52 (n-5) per 10^4 cells and that the Thy-1 positive cell was 2.3±2.1 percent. NSP treated group showed the decrease in number of ARFC, 90±35,and the increase of Thy-1 positive cells, 17.9±4.4 percent. The maximal decrease and increase were obtained with the dose of 20 mg/kg at 4 days after the treatment. These results suggested that ARFC belonged to immature T-cell subset, and that NSP was capable of activating and differentiating the immature T-cell subset.
近畿大学の論文
1982-03-25

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