Therapeutic plasmapheresis and lymphocytapheresis

概要

論文の詳細を見る
Ten patients with autoimmune diseasee (SLE in six cases, two RA, one PM, one MCTD) were subjected to lymphocytapheresis. Clinical responses were good in five patients. Increased rate of IgM in serum between immediately after and fourteen days after lymphocytapheresis were higher the patients with poor clinical responses than the good ones.Fourteen patients with autoimmune diseases (SLE in eight cases, three PSS, two PM, one RA) were subjected to double filtration plasmapheresis (DEPP). Clinical findings, especially Raynaud's phenomenon, fatigue, erythema and arthralgia, had good responses in nine patients. Percentage of decreased IgM in serum between before and after treated with DFPP were higher good responders than fair patients. It was suggested that improvements of clinical features have mutual relation with changes on viscosity induced by DFPP. Immunological indicators, such as OKT series, PHA, Con A and IL-2 responses, were no significant differences between before and after apheresis.
日本臨床免疫学会の論文