<Originals>Induction of lymphokine-activated killer (LAK) cells from tumor-bearer's splenocytes and their application to adoptive immunotherapy

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概要

• 論文の詳細を見る

• We attempted to generate the LAK cells from tumor-bearer's spleens and to use them as effectors for adoptive immunotherapy. We investigated whether tumor-bearer's splenocytes cultured with interleukin-2 (IL-2) in vitro could lyse various tumor targets and whether these effectors were applicable to immunotherapeutic potentials. In vitro cytotoxicity tests revealed that these LAK cells generated from tumor-bearer's splenocytes exhibited potent cytotoxicity. These LAK cells exhibited antitumor effects in a tumor neutralization assay (Winn assay) in vivo. Furthermore, LAK cells infused intravenously into syngeneic mice with systemic metastasis significantly lengthened survival time compared with the control mice given cultured cells without interleukin-2 (IL-2). These results suggest that the use of LAK cells from tumor-bearer's splenocytes may provide a valuable method for the adoptive therapy of human neoplasms as well.

• 近畿大学の論文

著者

• Iwasa Z

  First Department Of Surgery Kinki University School Of Medicine

• Iwasa Zenji

  First Department Of Surgery Kinki University School Of Medicine

• NAKAMURA Tetsuhiko

  First Department of Surgery, Kinki University School of Medicine

• Ohnishi Hiroaki

  The First Department Of Surgery Kinki University School Of Medicine

• Yasutomi Masayuki

  First Department Of Surgery Kinki University School Of Medicine

• Yasutomi Masayuki

  Department Of Surgery Kinki University School Of Medicine

• Takagi Hiromi

  First Department Of Surgery Kinki University School Of Medicine

• Okuno K

  Department Of Surgery Kinki University School Of Medicine

• Okuno Kiyotaka

  First Department Of Surgery Kinki University School Of Medicine

• Yasutomi M

  Department Of Surgery Kinki University School Of Medicine

• Yasutomi Masayuki

  The 2nd Department Of Surgery Osaka University Medical School

• Okuno Kiyotaka

  Department of Surgery, Kinki University School of Medicine

• Minami Yasunori

  Departments Of Gastroenterology And Hepatology Kinki University School Of Medicine

• Ohnishi Hiroaki

  First Department Of Internal Medicine Kagawa Medical University

• Yasutomi Masayuki

  The First Department Of Surgery Kinki University School Of Medicine

• Nakamura Tetsuhiko

  First Department Of Surgery Kinki University School Of Medicine

• Iwasa Zenji

  Department Of Surgery Osaka University Medical School

• Iwasa Zenji

  The 2nd Department Of .surgery Osaka University Medical School

• Yasutomi Masayuki

  Department Of Surgery Osaka University Medical School

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