<Originals>Tegafur plus Medroxyprogesterone acetate for Adriamycin- and Tamoxifen-resistant advanced breast cancers

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概要

• 論文の詳細を見る

• A total of 32 patients with advanced breast cancer whose tumors were resistant to both adriamycin (ADR) and tamoxifen (TAM) were treated with combined chemoendocrine treatment with tegafur and medroxyprogesterone acetate (MPA). The daily dose of tegafur and MPA was 800mg/body. Two patients were assessed as complete response (CR), 8 as partial response (PR), 12 as no change (NC) and 10 as progressive disease (PD). The overall response rate was 31% (95% CI : 16.1-50.0%). A better response was observed in estrogen receptor (ER) positive and unknown patients than in ER negative patients, and in the patients with long disease-free intervals than in those with short intervals. The 50% survival period by the Kaplan Meier method was 88 weeks and the median duration of response was 14 weeks. Good quality of life was maintained during treatment because of lowered side effects. Tegafur plus MPA therapy is useful for the treatment of advanced breast cancers which are resistant to ADR and TAM.

• 近畿大学の論文

著者

• Nishiyama Kouichiro

  First Department Of Surgery Kinki University School Of Medicine

• YASUTOMI Masayuki

  First Department of Surgery, Kinki University School of Medicine

• Yayoi Eiji

  Osaka Teishin Hospital

• Yamauchi Eiju

  Osaka Teishin Hospital

• INUI HIROKI

  First Department of Surgery, Kinki University School of Medicine

• YAMAUCHI EIJU

  First Department of Surgery, Kinki University School of Medicine

• WADA Tomio

  First Department of Surgery, Kinki University School of Medicine

• HOUJOU Toshiya

  First Department of Surgery, Kinki University School of Medicine

• NAKATANI Yoshihiro

  First Department of Surgery, Kinki University School of Medicine

• Yasutomi Masayuki

  First Department Of Surgery Kinki University School Of Medicine

• Wada Tomio

  First Department Of Surgery Kinki University School Of Medicine.

• Inui H

  Department Of Surgery Kinki University School Of Medicine

• Inui Hiroki

  First Department Of Surgery Kinki University School Of Medicine

• Houjou Toshiya

  Department Of Surgery Kinki University School Of Medicine

• Hojo Toshiya

  Department Of Surgery Kinki University School Of Medicine

• Nakatani Yoshihiro

  First Department Of Surgery Kinki University School Of Medicine.

• Nagayama Koichi

  First Department Of Surgery Kinki University Medical School

• Nishimura Keisuke

  First Department Of Surgery Kinki University School Of Medicine

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