<Originals>The serum half-life of exogenous human recombinant interleukin-2 in a dog model

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概要

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• The clearance of exogenous recombinant human interleukin-2 (hIL-2) was characterized in a dog model. The titer of recombinant hIL-2 activity was measured using a radioimmunoassay. Intravenously injected hIL-2 disappeared from the blood circulation rapidly with a serum half life of 4.5±0.1 minutes (mean±SD). The reason for the short half life of i.v. injected hIL-2 was studied. To determine whether hIL-2 has been bound or consumed by peripheral blood lymphocyte (PBL) or serum, the IL-2 titer that has been cultured with PBL or serum in vitro was measured. No inhibitable effect of either lymphocyte and serum on the initial titer of cultured IL-2 could be detected. Interestingly, a surgical bilateral renal block on the dog greatly extended the serum half life of hIL-2 to 33.9±2.7 minutes. Administered hIL-2 was not excreted in a detectable form in the urine either the control or experimental group. These findings demonstrated that the kidney is the major organ to metabolize IL-2,possibly renal tubular catabolism.

• 近畿大学の論文

著者

• KOH Kenzo

  First Department of Surgery, Kinki University School of Medicine

• Koh K

  First Department Of Surgery Kinki University School Of Medicine

• Ohnishi Hiroaki

  The First Department Of Surgery Kinki University School Of Medicine

• Yasutomi Masayuki

  Department Of Surgery Kinki University School Of Medicine

• Okuno K

  Department Of Surgery Kinki University School Of Medicine

• Yasutomi M

  Department Of Surgery Kinki University School Of Medicine

• Yasutomi Masayuki

  The 2nd Department Of Surgery Osaka University Medical School

• Okuno Kiyotaka

  Department of Surgery, Kinki University School of Medicine

• Minami Yasunori

  Departments Of Gastroenterology And Hepatology Kinki University School Of Medicine

• Yasutomi Masayuki

  The First Department Of Surgery Kinki University School Of Medicine

• OKUNO Kiyotaka

  The First Department of Surgery, Kinki University School of Medicine

• KOH Kenzo

  The First Department of Surgery, Kinki University School of Medicine

• Yasutomi Masayuki

  Department Of Surgery Osaka University Medical School

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