Serum Folate and Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism Adjusted for Folate Intake
スポンサーリンク
概要
- 論文の詳細を見る
Background: Serum folate concentration is lower in individuals with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype than in those with the MTHFR 677CC or 677CT genotypes. Since studies considering folate intake are limited, we examined the association between folate intake and serum folate levels, according to the genotype.Methods: The subjects comprised 170 Japanese persons (74 males and 96 females) aged 20-75 years who visited a clinic to test for Helicobacter pylori infection. Folate intake was estimated using a semiquantitative foodfrequency questionnaire, and serum folate was measured in the residual fasting blood samples of the subjects. MTHFR C677T was genotyped using polymerase chain reaction.Results: The geometric means of serum folate level were 6.19, 6.20, and 5.17 ng/mL among the 60 participants with the 677CC genotype, 90 participants with the 677CT genotype, and 20 participants with the 677TT genotype, respectively. No difference was noted in the mean folate intake estimated using the food-frequency questionnaire. Regression analysis showed that loge(serum folate) adjusted for age, sex, and loge(folate intake) was significantly lower among those with the 677TT genotype than among those with the 677CT or 677CC genotypes (p = 0.01). The adjusted reduction in serum folate was 20.2% (95% confidence interval, 5.4-32.6%) in the case of the 677TT genotype relative to the levels in the case of the 677CC/677CT genotypes. When folate intake was adjusted for total energy intake, using the residual method, the slope of the regression line for 677TT was smaller than those of the regression lines for 677CC and 677CT.Conclusion: Individuals with the 677TT genotype may need to consume more folate to maintain serum folate levels similar to those found in individuals with the 677CC/677CT genotypes.
- 日本疫学会の論文
- 2008-05-01
著者
-
WAKAI Kenji
Department of Clinical Epidemiology, University of Occupational and Environmental Health
-
Ito Yoshinori
Department Of Public Health Fujita Health University School Of Health Sciences
-
Ito Yoshinori
札幌医科大学 医学部公衆衛生学
-
KONDO Takaaki
Department of Medical Technology, Nagoya University School of Health Sciences
-
Kondo Takaaki
Department Of Cardiology Nagoya University Graduate School Of Medicine
-
Wakai K
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
-
Wakai Kenji
愛知医科大学 医学部公衆衛生学講座
-
Wakai Kenji
愛知県がんセンター研究所 疫学予防部
-
Ito Yoshinori
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
-
HAMAJIMA Nobuyuki
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Gradu
-
ISHIDA Yoshiko
Department of Occupational Therapy, Faculty of Health and Walfare, Prefectural University of Hiroshi
-
INABA Yutaka
Juntendo University School of Medicine
-
Hatsumi Naoko
Japan Adult Leukemia Study Group Hamamatsu Jpn
-
Inaba Yutaka
愛知医科大学 公衆衛生学
-
Nishio Kazuko
Department of Preventive Medicine
-
Kondo Takaaki
Department Of Health Science Shiga University Of Medical Science
-
Tamakoshi Akiko
京都府立医科大学 地域保健医療疫学
-
Kondo Takaaki
名古屋大学 医学研究科環境病因解析学部門
-
Kadowaki Takashi
滋賀大学 医学部健康科学科
-
GOTO Yasuyuki
Department of Neurology, School of Medicine, Sao Paulo University
-
Hamajima N
Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua
-
Hamajima Nobuyuki
愛知県がんセンター研究所 疫学･予防部
-
Hamajima Nobuyuki
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
-
Inaba Y
Juntendo Univ. School Of Medicine
-
Ishida Yoshiko
Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua
-
Ishida Yoshiko
Department Of Occupational Therapy Faculty Of Health And Walfare Prefectural University Of Hiroshima
-
Naito Mariko
Nagoya Univ. Graduate School Of Medicine Nagoya Jpn
-
Naito Mariko
Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua
-
Tamakoshi A
Department Of Health Science Shiga University Of Medical Science
-
Kato Norihiro
Department Of Gene Diagnostics And Therapeutics Research Institute International Medical Center Of J
-
Kawai Sayo
Department of Preventive Medicine-Biostatistics and Medical Decision Making, Nagoya University Gradu
-
ITO Shimon
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Gradu
-
Hamajima Nobuyuki
Department Of Preventive Medicine Aichi Cancer Center Research Institute
-
Hamajima Nobuyuki
Cancer Information Service And Surveillance Division Cancer For Cancer Control And Information Servi
-
Hamajima Nobuyuki
Department Of Preventive Medicine
-
Tamakoshi Koji
Dep. Of Public Health - Health Information Dynamics Nagoya Univ. Graduate School Of Medicine
-
Inaba Y
Department Of Physics University Of Tokyo
-
NAKAMURA Kenjiro
Tenjin Sogo Clinic
-
Takagi Kenzo
Third Division Of The Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku Un
-
Takagi Kenzo
School Of Health Sciences Nagoya University
-
Nakamura Kazuyo
Department Of Preventive Medicine Faculty Of Medicine Saga University
-
Nakagawa H
Department Of Public Health Kanazawa Medical University
-
Kawase Takakazu
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
-
Takemiya Kiyoko
Department Of Internal Medicine Division Of Cardio-vascular Medicine Kurume University School Of Med
-
Takagi K
Department Of Public Health Miyazaki Medical College University Of Miyazaki
-
Kondo Takaaki
名古屋大学 医学部保健学科
-
Inaba Y
Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine
-
Kawai Sayo
Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua
-
Goto Yasuyuki
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
-
Goto Yasuyuki
Department Of Electrical And Electronics Engineering Aichi Institute Of Technology
-
Kawazoe Seiji
Department Of Internal Medicine Saga Prefectural Hospital Koseikan
-
Hoki Noriyuki
Department Of Gastroenterology Aichi Cancer Center Hospital
-
Kondo Takaaki
Dep. Of Medical Technol. Nagoya Univ. School Of Health Sciences 1-1-20 Daikominami Higashi-ku Nagoya
-
Hamajima N
Department Of Preventive Medicine Biostatistics And Medical Decision Making Nagoya University Gradua
-
Tokunaga Katsushi
Department Of Clinical Pharmacology And Therapeutics Tohoku University
-
Kondo Takaaki
Department Of Medical Technology Nagoya University School Of Health Science
-
Nishio Kazuko
Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua
-
Hirabayashi Noriyuki
Department Of Hematology Nagoya Daini Red Cross Hospital
-
Kadowaki Sayaka
Department Of Health Science Shiga University Of Medical Science
-
Ito Shimon
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
-
Kuzuya T
Department Of Hospital Pharmacy Nagoya University School Of Medicine
-
Naito Mariko
Department Of Molecular Microbiology And Immunology Division Of Microbiology And Oral Infection Grad
-
Inaba Yutaka
Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University
-
Naito Mariko
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
-
Wakai Kenji
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
-
Ito Yoshinori
Department Of Preventive Medicine - Biostatistics And Medical Decision Making Nagoya University Grad
-
Nakao Makoto
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
-
Hatsumi Naoko
Leukemia Research Center Saiseikai Maebashi Hospital
-
Kawai Sayo
Department Of Preventive Medicine Nagoya University Graduate School Of Medicine
-
Ito Yoshinori
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
-
Nagatsuka Kazuyuki
Department Of Medicine And Clinical Sciences Graduate School Of Medicine Kyoto University
-
Hamajima Nobuyuki
Department of Epidemiology and Public Health, Kanazawa Medical University
-
INABA Yutaka
Department of Physics, University of Tokyo
関連論文
- Association of Serum Phytoestrogen Concentration and Dietary Habits in a Sample Set of the JACC Study
- Sleeping Habit and Other Life Styles in the Prime of Life and Risk for Ossification of the Posterior Longitudinal Ligament of the Spine (OPLL) : a Case-control Study in Japan
- Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese
- A Review of Food Frequency Questionnaires Developed and Validated in Japan
- Smoking, drinking, sleeping habits, and other lifestyle factors and the risk of systemic lupus erythematosus in Japanese females : findings from the KYSS study
- Effects of Passive Smoking on Serum Levels of Carotenoids and α-Tocopherol
- Frequent Hard Physical Activity Lowered Serum β-Carotene Level in a Population Study of a Rural City of Japan
- Association between Interleukin-1B C-31T Polymorphism and Obesity in Japanese
- Association of a Polymorphism in the Ornithine Decarboxylase Gene with Whole Blood Polyamine Concentrations in a Non-smoking Healthy Population
- Diabetes mellitus and kidney cancer risk : The results of Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study)
- Association of Abdominal Circumference with Serum Nitric Oxide Concentration in Healthy Population
- Cardiovascular Disease Mortality and Serum Carotenoid Levels : a Japanese Population-based Follow-up Study
- Alcohol Consumption and Lung Cancer Mortality in Japanese Men : Results from Japan Collaborative Cohort (JACC) Study
- Blood Pressure, Levels of Serum Lipids, Liver Enzymes and Blood Glucose by Aldehyde Dehydrogenase 2 and Drinking Habit in Japanese Men
- Genotype Announcement to Japanese Smokers Who Attended a Health Checkup Examination
- Association of Serum Carotenoid Concentration and Dietary Habits among the JACC Study Subjects
- Risk Factors for Kidney Cancer in a Japanese Population : Findings from the JACC Study
- Dietary Habits and Risk of Urothelial Cancer Incidence in the JACC Study
- Colorectal Cancer and Serum C-reactive Protein Levels : a Case-control Study Nested in the JACC Study
- Glucose Intolerance and Colorectal Cancer Risk in a Nested Case-Control Study among Japanese People
- Alcohol Consumption and Colorectal Cancer Risk : Findings from the JACC Study
- Medical History of Circulatory Diseases and Colorectal Cancer Death in the JACC Study
- Lung Cancer Mortality and Serum Levels of Carotenoids, Retinol, Tocopherols, and Folic Acid in Men and Women : a Case-Control Study Nested in the JACC Study
- Updated Information on Risk Factors for Lung Cancer : Findings from the JACC Study
- Preface
- Stability of Frozen Serum Levels of Insulin-like Growth Factor-I, Insulin-like Growth Factor-II, Insulin-like Growth Factor Binding Protein-3, Transforming Growth Factorβ, Soluble Fas, and Superoxide Dismutase Activity for the JACC Study
- Seasonal Variation of Trace Element Loss to Sweat during Exercise in Males
- Concentrations of Trace Elements in Sweat during Sauna Bathing
- Epidemiologic and Clinical Characteristics of Cardiomyopathies in Japan : Results From Nationwide Surveys
- Dietary Habits and Risk of Lung Cancer Death in a Large-scale Cohort Study (JACC Study) in Japan by Sex and Smoking Habit
- Decrease in Risk of Lung Cancer Death in Males after Smoking Cessation by Age at Quitting : Findings from the JACC Study
- Tea Consumption and Lung Cancer Risk : A Case-Control Study in Okinawa, Japan
- Serum carotenoids and mortality from lung cancer : a case-control study nested in the Japan Collaborative Cohort (JACC) Study
- Associations of Lifestyle Factors with Bone Mineral Density among Male University Students in Japan
- The Relationship between Smoking Habits and Serum Levels of 8-OHdG, Oxidized LDL Antibodies, Mn-SOD and Carotenoids in Rural Japanese Residents
- Relation of Serum C-reactive Protein Level to Obesity and Fat Distribution in Japanese
- Depressive Mood and Suicide Among Middle-Aged Workers : Findings from a Prospective Cohort Study in Nagoya, Japan
- Prognosis and Prognostic Factors in Patients With Idiopathic Dilated Cardiomyopathy in Japan : Results From a Nationwide Study
- Baseline data of Shizuoka area in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study)
- CONTROLS FOR MONITORING THE DETERIORATION OF STORED BLOOD SAMPLES IN THE JAPAN MULTI-INSTITUTIONAL COLLABORATIVE COHORT STUDY (J-MICC STUDY)
- Serum Folate and Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism Adjusted for Folate Intake
- No Association Between Helicobacter Pylori Seropositivity and Ornithine Decarboxylase (ODC) A317G Polymorphism, and No Modification by NAD(P)H : Qinone Oxidoreductase 1 (NQO1) C609T
- One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma : Case-control study
- Coffee consumption and the risk of endometrial cancer : Evidence from a case-control study of female hormone-related cancers in Japan
- Active Smoking, Passive Smoking, and Breast Cancer Risk : Findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk
- Estimated Number of Patients with Chronic Renal Failure but not with End-Stage Renal Disease in Japan : Comparisons Between Two Estimation Methods
- Predialysis Serum Albumin Concentration and Creatinine Generation Rate Do Not Reflect the Same Pathophysiologic Status
- Foods and beverages in relation to urothelial cancer : Case-control study in Japan
- Validity and Reliability of Single-item Questions about Physical Activity
- Estimated Prevalence and Incidence of Adult Still's Disease : Findings by a Nationwide Epidemiological Survey in Japan
- Case-Control Study of Oral Cancer in Shenyang, Northeastern China
- Serum phytoestrogens and prostate cancer risk in a nested case-control study among Japanese men
- Similar and Dissimilar Findings in Japan-Indonesia Case-Control Study on Breast Cancer : Two Phases Study
- Nationwide epidemiological survey of chronic pancreatitis in Japan
- Sleep Patterns and Total Mortality : A 12-Year Follow-up Study in Japan
- A Study on How a 6-Month Aerobic Exercise Program Can Modify Coronary Risk Factors Depending on Their Severity in Middle-Aged Sedentary Women
- Relationship between dietary habits and urinary concentrations of 3-phenoxybonzoic acid in a middle-aged and elderly general population in Japan
- Newly Developed Diabetic Retinopathy and Its Preceding Changes in Biological Markers
- Estimated Prevalence of Sjogren's Syndrome in Japan : Findings from a Nationwide Epidemiological Survey
- Reproducibility and Validity of a Simple Checklist-type Questionnaire for Food Intake and Dietary Behavior
- Association of serum carotenoids, retinol, and tocopherols with radiographic knee osteoarthritis : possible risk factors in rural Japanese inhabitants
- Association of serum NO_x level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan
- Relationship Between Serum Carotenoid Levels and Cancer Death Rates in the Residents, Living in a Rural Area of Hokkaido, Japan
- Rationale, Design, and Profiles of the New Integrated Suburban Seniority Investigation (NISSIN) Project : A Study of an Age-Specific, Community-Based Cohort of Japanese Elderly
- Written Informed Consent for Participation in a Study and Reduction in Consent Rate
- Serum Insulin-like Growth Factors, Insulin-like Growth Factor-biding Protein-3, and Risk of Lung Cancer Death : A Case-control Study Nested in the Japan Collaborative Cohort (JACC) Study
- Mortality Rates from Cancer or All Causes and SOD Activity Level and Zn/Cu Ratio in Peripheral Blood : Population-based Follow-up Study
- Smoking Habits, Local Brand Cigarettes and Lung Cancer Risk in Okinawa, Japan
- Out-of-Hospital Cardiac Arrest and Survival : An Epidemiological Analysis of Emergency Service Reports in a Large City in Japan
- Maternal Active and Passive Smoking and Fetal Growth : A Prospective Study in Nagoya, Japan
- A Simple Food Frequency Questionnaire for Japanese Diet : Part II. Reproducibility and Validity for Nutrient Intakes
- A Simple Food Frequency Questionnaire for Japanese Diet : Part I. Development of the Questionnaire, and Reproducibility and Validity for Food Groups
- Descriptive Epidemiology of Pancreatic Cancer in Japan
- Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese
- Rationale, Design, and Profiles of the New Integrated Suburban Seniority Investigation (NISSIN) Project: A Study of an Age-Specific, Community-Based Cohort of Japanese Elderly
- Agreement Between Self- and Partner Reports Obtained by a Self-Administered Questionnaire : Medical and Lifestyle Information
- Associations of Periodontal Damage and Tooth Loss with Atherogenic Factors among Patients with Type 2 Diabetes Mellitus
- Serum Cholesterol and Cancer Mortality in Japanese Civil Service Workers : Findings from a Nested Case-control Study
- Associations of Lifestyle Factors with Bone Mineral Density among Male University Students in Japan
- Epidemiology of Intractable Diseases in Japan
- Epidemiology of Diseases of Unknown Etiology, Specified as "Intractable Diseases"
- Reproducibility and Validity of a Simple Checklist-type Questionnaire for Food Intake and Dietary Behavior
- Longitudinal Evaluation of Multi-phasic, Odontological and Nutritional Associations in Dentists (LEMONADE Study) : Study Design and Profile of Nationwide Cohort Participants at Baseline
- The Relationship between Smoking Habits and Serum Levels of 8-OHdG, Oxidized LDL Antibodies, Mn-SOD and Carotenoids in Rural Japanese Residents
- No association between the frequency of forest walking and blood pressure levels or the prevalence of hypertension in a cross-sectional study of a Japanese population
- Body Mass Index and Mortality From All Causes and Major Causes in Japanese : Results of a Pooled Analysis of 7 Large-Scale Cohort Studies
- An Overview of Genetic Polymorphisms and Pancreatic Cancer Risk in Molecular Epidemiologic Studies
- The Effect of Serum Carotenoids on Atrophic Gastritis Among the Inhabitants of a Rural Area in Hokkaido, Japan
- Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors : A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study
- Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese-a cross-sectional data from the J-MICC Study
- Correlation of pathological grade and tumor stage of urothelial carcinomas with CD109 expression
- Body Mass Index and Weight Change During Adulthood Are Associated With Increased Mortality From Liver Cancer: The JACC Study
- Obesity/Weight Gain and Breast Cancer Risk: Findings From the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk
- Risk Factors for Breast Cancer among Japanese Women in Tokyo : A Case-Control Study
- O-33 The Associations of Oral Health-related Quality of Life with Stress in Japanese Men and Women
- Significant interaction between RETN-420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese : the J-MICC Study
- Obesity/Weight Gain and Breast Cancer Risk : Findings From the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk
- Low Intake of Vegetables and Fruits and Risk of Colorectal Cancer: The Japan Collaborative Cohort Study
- Coffee Consumption and Risk of Colorectal Cancer: The Japan Collaborative Cohort Study
- Body Mass Index and Weight Change During Adulthood Are Associated With Increased Mortality From Liver Cancer : The JACC Study