Development, Strength and Functional Evaluation of Plastic Microneedle Array Fabricated by Injection Molding

概要

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We hereby fabricated the microneedle arrays whose dimensions of 300 μm in height, 100 and 150 μm in diagonal lengths of bottom surface and with densities of 900 and 4,400 needles/ cm2 by injection molding. The resist patterns were pre-formed by three-dimensional fine manufacturing with movable resist during the exposure in LIGA process. Polylactic acid was used for microneedle arrays in consideration of the prospective medical use in transdermal methods and the like. Our study was to evaluate the material filling of the needle tips and dermal penetrability. The flexibility of the needle tips was also tested by the force added to the tips, and its result was compared with the analysis of flexibility by CAE; computer aided experiment. The resin filling did not reach to the deepest point of the Ni stamper, and the filling remained within the range of 12 to 17 μm in diameter. However, the penetration rate on pig skin with the density of 900 needles / cm2 resulted in the range of 60 to 80%, and this result represented the satisfactory capability of dermal penetration in spite of the previously described needle tip dimensions of microneedle array. Closely resembling needle flexibility to its analysis proved that CAE analysis on the strength of microstructures was well effective.
社団法人電気学会の論文
2004-10-01