Direct Electrical Detection of DNA Hybridization Based on Electrolyte-Gated Graphene Field-Effect Transistor

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概要

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• DNA hybridization was electrically detected by graphene field-effect transistors. Probe DNA was modified on the graphene channel by a pyrene-based linker material. The transfer characteristic was shifted by the negative charges on the probe DNA, and the drain current was changed by the full-complementary DNA while no current change was observed after adding noncomplementary DNA, indicating that the graphene field-effect transistor detected the DNA hybridization. In addition, the number of DNAs was estimated by the simple plate capacitor model. As a result, one probe DNA was attached on the graphene channel per 10\times 10 nm², indicating their high density functionalization. We estimated that 30% of probe DNA on the graphene channel was hybridized with 200 nM full-complementary DNA while only 5% of probe DNA was bound to the noncomplementary DNA. These results will help to pave the way for future biosensing applications based on graphene FETs.

• 2013-11-25

著者

• Maehashi Kenzo

  The Institute Of Scientific And Industrial Research Osaka University

• Ohno Yasuhide

  The Institute Of Scientific And Industrial Research Osaka University

• Matsumoto Kazuhiko

  The Institute Of Scientific And Industrial Research Osaka University

• Okamoto Shogo

  The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan

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