A Complementary Metal–Oxide–Semiconductor Image Sensor for On-Chip in Vitro and in Vivo Imaging of the Mouse Hippocampus
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概要
- 論文の詳細を見る
This paper describes the development of a complementary metal–oxide–semiconductor (CMOS) image sensor for in vitro and in vivo imaging of the hippocampus. The $176\times 144$ pixel array image sensor is designed based on a modified three-transistor active pixel sensor circuit. Flexibility in readout for real-time imaging and wide dynamic range measurement is implemented using analog and digital output. A minimum light intensity detection level of 50 nW/cm2 has been measured using the image sensor. A novel packaging method is developed to enable both in vitro and in vivo imaging. In this method, a color filter is applied onto the image sensor that selectively blocks excitation light transmittance to below $-44$ dB. The packaged device thickness measuring 350 μm, limits tissue damage during invasive imaging. Using the device, static images of the mouse brain slice and real time imaging of the hippocampus of a mouse are successfully demonstrated for the first time.
- Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
- 2006-04-30
著者
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Shiosaka Sadao
Graduate School Of Materials Science Nara Institute Of Science And Technology
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Nunoshita Masahiro
Graduate School Of Materials Science Nara Institute Of Science And Technology
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NG David
Graduate School of Materials Science, Nara Institute of Science and Technology
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Ohta Jun
Graduate School Of Materials Science Nara Institute Of Science And Technology
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Tokuda Takashi
Graduate School Of Materials Science Nara Institute Of Science And Technology
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Tamura Hideki
Graduate Program Of Human Sensing And Functional Sensor Engineering Yamagata University
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Yamamoto Akio
Graduate School Of Energy Science Kyoto University
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Ishikawa Yasuyuki
Graduate School of Biological Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
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Ishikawa Yasuyuki
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
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Matsuo Masamichi
Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
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Ng David
Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
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Nunoshita Masahiro
Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
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Shiosaka Sadao
Graduate School of Biological Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
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Shiosaka Sadao
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
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Nunoshita Masahiro
Graduate School of Material Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0101, Japan
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Ohta Jun
Graduate School of Material Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0101, Japan
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