Vasoactive Substances in Hypertensive Disorders
スポンサーリンク
概要
- 論文の詳細を見る
We have studied on the role of vasoactive substances in pathogenesis of hypertension in man. The results can be summarized as follows: <BR>Renin-Angiotensin-Aldosterone RAA System<BR>RAA system is not elevated in the majority of patients with essential hypertension. It is activated in patients with renovascular hypertension, and with hypertension due to toxemia of pregnancy. In primary aldosteronism, a characteristic dissociation is observed between aldosterone secretion rate and plasma renin activity; an increase in the former in the face of a decrease in the latter.<BR>Catecholamines<BR>Fifteen patients with pheochromocytoma have been studied, and a marked increase in excretion of catecholamines or their metabolites have been confirmed in all the cases.<BR>Patients with essential hypertension showed no difference in catecholamine excretion or its metabolic pattern from control subjects. In these patients, however, responses of blood pressure to vasopressor substances(noradrenaline, angiotensin)as well as vasodepressor substance(eledoisin)are excessive when compared with controls. When their blood pressure is lowered by eledoisin infusion, the sympathetic response, which is normally observed in controls and is reflected on an increased excretion of noradrenaline in urine, does not occur in them. It is likely that the counter-regulation of the sympathetic nervous system against the effects of introduced pressor or depressor substance is deficient in hypertensive patients.<BR>Kallikrein-Kinin System<BR>There is no difference in urinary excretion of this system, kallikrein and kinin, between hypertensive and control groups. Blood kinin levels are also normal in primary hypertension.<BR>Arneil Factor<BR>This pressor factor is detectable in all the subjects tested. The estimated values tend to be high in hypertensive patients, but considerable overlap with controls is also observed. The factor may be aphysiological principle in maintenance of blood pressure. More detailed study is now under progress.
著者
-
阿部 圭志
東北大学医学部第二内科
-
佐藤 辰男
東北大学医学部鳥飼内科
-
前橋 賢
東北大学医学部
-
吉永 馨
東北大学医学部付属病院長
-
三浦 幸雄
東北大学医学部第2内科学教室
-
前橋 賢
東北大学医学部鳥飼内科
-
三浦 幸雄
東北大学医学部鳥飼内科
-
三浦 幸雄
東北大学医学部第2内科
-
佐藤 辰男
東北大学医学部第二内科
-
佐藤 辰男
東北大学医学部第2内科
-
阿部 圭志
東北大学医学部第2内科
-
阿部 圭志
東北大学医学部病態液性調節学
関連論文
- 全身性疾患に伴う腎疾患 悪性腎硬化症
- 家庭血圧の測定法の検討と評価 : 特に家庭血圧散布図による降圧治療の評価
- 腎性高血圧の病態・治療・予後
- 臨牀経験 TJ-15ツムラ黄連解毒湯の高血圧症随伴症状に対する二重盲検比較試験
- 腎臓領域の100年 : 4. 腎性高血圧
- 24時間血圧計の使用(ABPM)基準に関するガイドライン(循環器病の診断と治療に関するガイドライン(1998-1999年度合同研究班報告))
- 24時間血圧計の使用(ABPM)基準に関するガイドライン
- 血圧日内変動を考えた降圧薬療法
- ProstacyclinとThromboxane A_2の尿中安定代謝産物の同時定量法の開発と臨床応用
- キニン・カリクレイン