A Case of Slowly Progressive Type 1 Diabetes with Insulin Independence Maintained for 10 Years with α-glucosidase Inhibitor Monotherapy
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概要
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Slowly Progressive Type 1 Diabetes (SPT1D) is characterized by the absence of insulin dependence at the onset of diabetes and persistent detection of islet cell autoantibodies. These patients with high titers of glutamic acid decarboxylase autoantibodies (GADA) are known to progress to insulin dependence within several years. Low-dose insulin injections have been reported to prevent or delay the decline of insulin secretion in SPT1D patients. We experienced the case of an SPT1D patient with preserved endogenous insulin secretion and good glycemic control achieved with α-glucosidase inhibitor (α-GI) treatment alone for 10 years despite having continuously elevated GADA titers. The details of this case suggest that α-GI treatment might have preventive effects on SPT1D progression.
著者
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Sawada Shojiro
Department Of Internal Medicine National Defense Medical College
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Oka Yoshitomo
Department Of Medicine Faculty Of Medicine Yamaguchi University
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Katagiri Hideki
Department Of Anatomy Juntendo University School Of Medicine
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Yamada Tetsuya
Department Of Agricultural Chemistry Faculty Of Bioresources Mie University
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Takahashi Kazuma
Division Of Molecular Metabolism And Diabetes Department Of Internal Medicine Tohoku University Scho
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Takahashi Kei
Department of Applied Chemistry, School of Science and Engineering, Waseda University
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Takahashi Kei
Department of Diabetes and Metabolism, Tohoku University Hospital, Japan
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Munakata Yuichiro
Department of Diabetes and Metabolism, Tohoku University Hospital, Japan
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Tsukita Sohei
Department of Diabetes and Metabolism, Tohoku University Hospital, Japan
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Imai Junta
Department of Diabetes and Metabolism, Tohoku University Hospital, Japan
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Ishigaki Yasushi
Department of Diabetes and Metabolism, Tohoku University Hospital, Japan
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Imai Junta
Department of Diabetes and Metabolism, Tohoku University Hospital
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Ishigaki Yasushi
Department of Diabetes and Metabolism, Tohoku University Hospital
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Sawada Shojiro
Department of Diabetes and Metabolism, Tohoku University Hospital, Japan
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Oka Yoshitomo
Department of Diabetes and Metabolism, Tohoku University Hospital
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Takahashi Kazuma
Division of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University School of Medicine, Japan
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