Peginterferon (PEG-IFN) Plus Ribavirin Combination Therapy, but neither Interferon nor PGE-IFN Alone, Induced Type 1 Diabetes in a Patient with Chronic Hepatitis C
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概要
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Interferon (IFN) therapies, including IFN, peginterferon (PEG-IFN) and ribavirin (RBV) plus PEG-IFN combination, are widely used for patients with chronic hepatitis C. We encountered a patient with chronic hepatitis C in whom previous IFN or PEG-IFN alone had not induced type 1 diabetes (T1D), while the addition of RBV to PEG-IFN did induce T1D. The patient had HLA types conferring highly susceptibility to T1D. Thus, adding RBV to PEG-IFN may render chronic hepatitis C patients, with T1D-susceptible HLA types, more prone to developing T1D than IFN or PEG-IFN alone. To prevent T1D development, we recommend HLA typing prior to initiating RBV plus PEG-IFN administration.
著者
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Shimosegawa Tooru
Department Of Gastroenterology Tohoku University Graduate School Of Medicine
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Oka Yoshitomo
Department Of Medicine Faculty Of Medicine Yamaguchi University
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Katagiri Hideki
Department Of Anatomy Juntendo University School Of Medicine
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Yamada Tetsuya
Department Of Agricultural Chemistry Faculty Of Bioresources Mie University
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Ueno Yoshiyuki
Department Of Gastroenterology Division Of Internal Medicine Tohoku University Graduate School Of Me
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Yamagiwa Yoko
Department Of Gastroenterology Tohoku University Graduate School Of Medicine
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Shimosegawa Tooru
Department of Gastroenterology, Tohoku University Hospital
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Imai Junta
Department of Diabetes and Metabolism, Tohoku University Hospital
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Ishigaki Yasushi
Department of Diabetes and Metabolism, Tohoku University Hospital
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Ogihara Takehide
Department of Diabetes and Metabolism, Tohoku University Hospital
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Kudo Hirohito
Department of Diabetes and Metabolism, Tohoku University Hospital
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Hinokio Yoshinori
Department of Diabetes and Metabolism, Tohoku University Hospital
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Yamagiwa Yoko
Department of Gastroenterology, Tohoku University Hospital
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Oka Yoshitomo
Department of Diabetes and Metabolism, Tohoku University Hospital
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