Telomere Shortening of Peripheral Blood Mononuclear Cells in Coronary Disease Patients with Metabolic Disorders
スポンサーリンク
概要
- 論文の詳細を見る
Objective Telomere shortening is correlated with cell turnover and aging, but it has been recently suggested to occur not only by aging but by several biochemical factors of metabolic disorders predisposing to atherosclerosis. Patients and Methods We compared telomere length of peripheral blood mononuclear cells of patients with the metabolic disorders, hypercholesterolemia (HC) and diabetes mellitus (DM), according to the presence or absence of coronary diseases. Results The results demonstrated that HC and/or DM patients with coronary diseases have significantly shorter telomere length than healthy controls (p=0.0014). Conclusion Telomere shortening may be involved in the mechanisms that promote coronary diseases under some circumstances of metabolic disorders.(Internal Medicine 42: 150-153, 2003)
- 社団法人 日本内科学会の論文
- 2003-02-01
著者
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OIKAWA Shinichi
Division of Endocrinology and Metabolism, Department of Medicine, Nippon Medical School
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Kondo Yasuteru
Department Of Gastroenterology Tohoku University Graduate School Of Medicine
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SHIMOSEGAWA TOORU
Department of Gastroenterology, Tohoku University Graduate School of Medicine
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Oikawa Shinichi
Division Of Endocrinology And Metabolism Department Of Medicine Nippon Medical School
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Takagi Sho
Division Of Gastroenterology Department Of Internal Medicine Tohoku University Graduate School Of Me
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Shimosegawa Tooru
Department Of Gastroenterology Tohoku University Graduate School Of Medicine
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Takahashi Shin'ichi
Third Department Of Internal Medicine Kyorin University School Of Medicine
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HIWATASHI NOBUO
Department of Gastroenterology, Tohoku University Graduate School of Medicine
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Hiwatashi Nobuo
Department Of Gastroenterology Tohoku University Graduate School Of Medicine
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Kariya Yoshiyuki
Department Of Pathology Tohoku University Hospital
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OBANA NOBUYA
Division of Gastroenterology, Tohoku University Graduate School of Medicine
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TOKITA Yoshihisa
Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine
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SEKIKAWA Akihiro
Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine
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OBANA Nobuya
Department of Gastroenterology, Tohoku Univeisity Postgraduate School of Medicine
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TAKAGI Sho
Department of Gastroenterology, Tohoku Univeisity Postgraduate School of Medicine
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KINOUCHI Yoshitaka
Department of Gastroenterology, Tohoku Univeisity Postgraduate School of Medicine
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TOKITA Yoshihisa
Department of Molecular Metabolism and Diabetes
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SEKIKAWA Akihiro
Department of Molecular Metabolism and Diabetes
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TAKAHASHI Seiichi
Department of Gastroenterology, Tohoku Univeisity Postgraduate School of Medicine
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Takagi Sho
Department Of Pathology School Of Medicine Iwate Medical University
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Obana Nobuya
Department Of Gastroenterology Tohoku Univeisity Postgraduate School Of Medicine
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Kobayashi Yoshie
Division Of Gastroenterology Department Of Internal Medicine Tohoku University Graduate School Of Me
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Sekikawa Akihiro
Division Of Molecular Metabolism And Diabetes Tohoku University Graduate School Of Medicine
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Kinouchi Yoshitaka
Division Of Gastroenterology Tohoku University Hospital
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Kato Yuhei
Department Of Gastroenterology Sendai City Medical Center
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Takagi Sho
Department Of Gastroenterology Tohoku Univeisity Postgraduate School Of Medicine
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Tokita Yoshihisa
Division Of Molecular Metabolism And Diabetes Tohoku University Graduate School Of Medicine
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Hiwatashi Nobuo
Department Of Gastroenterology Iwaki Kyoritsu General Hospital
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Takahashi Seiichi
Department Of Electrical Engineering And Electronics Aoyama Gakuin University
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Oikawa Shinichi
Division Of Endocrinology And Metabolism Department Of Internal Medicine Nippon Medical School
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