Menatetrenone Ameliorates Reduction in Bone Mineral Density and Bone Strength in Sciatic Neurectomized Rats

スポンサーリンク

概要

• 論文の詳細を見る

• Vitamin K2 (menaquinone) acts on the bone metabolism. Menatetrenon (MK-4) is a vitamin K2 homologue that has been used as a therapeutic agent for osteoporosis in Japan. Rat models of immobilization induced by sciatic neurectomy are characterized by transiently increased bone resorption and sustained reduction in bone formation. Using such a rat model, we investigated the efficacy of MK-4 on bone loss. Male Sprague-Dawley rats were subjected to unilateral sciatic neurectomy and administered MK-4 for 28 d beginning day 21 after operation. The effect of MK-4 on the immobilized bone was assessed by measuring the bone mineral density of the femur, breaking force of the femoral diaphysis, and bone histomorphometry in tibial diaphysis. The BMD on both the femoral distal metaphysis and diaphysis was reduced by sciatic neurectomy. The administration of MK-4 ameliorated this reduction in a dose-dependent manner. The administration of 30mg/kg MK-4 ameliorated the reduction in bone strength. An improvement in bone formation was observed following the administration of MK-4. These results suggest that MK-4 has a therapeutic potential for immobilization-induced osteopenia.

著者

• Ezawa Ikuko

  Department Of Food And Nutrition Japan Women's University

• Fukagawa Masafumi

  Division Of Nephrology And Dialysis Center Kobe University Graduate School

• YAMATO Hideyuki

  Biomedical Research Laboratories, Kureha Chemical Ind. Ltd.

• MURAYAMA Hisashi

  Biomedical Research Laboratories, Kureha Chemical Ind. Ltd.

• Yamato Hideyuki

  Biomedical Research Laboratories Kureha Chemical Co. Ltd.

• Abe Masako

  Department Of Clinical Genetics Medical Institute Of Bioregulation Kyushu University

• Murayama Hisashi

  Biomedical Research Laboratories Kureha Chemical Ind. Ltd.

• Iwasaki-Ishizuka Yoshiko

  Department of Health Sciences, Oita University of Nursing and Health Sciences

• Kurokawa Kiyoshi

  Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai University

• FUKAGAWA Masafumi

  Division of Nephrology and Dialysis Center, Kobe University School of Medicine

• Takahashi Kei

  Department of Applied Chemistry, School of Science and Engineering, Waseda University

• KUROKAWA Kiyoshi

  Division of Nephrology, Tokai University School of Medicine

• EZAWA Ikuko

  Department of Biochemistry, Faculty of Dentistry, Tokyo Medical and Dental University

関連論文

• Effect of Fasting on the Urinary Excretion of Water-Soluble Vitamins in Humans and Rats
• Clinical Practice Guidebook for Diagnosis and Treatment of Chronic Kidney Disease
• -0274-AN EXPERIMENTAL STUDY OF THE INFLUENCE ON THE MYOCARDIAL TISSUE AND ON THE TRICUSPID VENTRICULAR BLOCK BY RADIOFREQUENCY CATHETER ABLATION
• 卵巣摘出骨粗鬆症モデルラットの骨代謝に対する卵殻カルシウムの効果およびおよび1α(OH)D_3投与効果の検討
• 微小重力環境下での骨量減少の機序 : 成熟期ラットを用いた検討
• Beta-Mannosyl Linkages Negatively Regulate Anaphylaxis and Vasculitis in Mice, Induced by CAWS, Fungal PAMPs Composed of Mannoprotein-Beta-Glucan Complex Secreted by Candida albicans(Highlighted paper selected by Editor-in-chief,Microbiology)
• 骨粗鬆症ラットを用いた自由ランニング運動とスイミング運動における血中レプチン値とIGFBP-3値の変動について
• 低カルシウム食で飼育した卵巣摘出ラットの骨密度低下に対するイソフラボンアグリコンを含有する大豆発酵抽出物の予防効果
• Clinical Implications of Assessing Coronary Flow Velocity Reserve and Plasma Endothelin-1 in Hypertensive Patients
• Expression of RET in follicular cell-derived tumors of the thyroid gland : Prevalence and implication of morphological type
• Inhibitory Effect of Thyrotropic Hormone on Apoptosis Induced by Actinomycin D in a Functioning Rat Thyroid Cell Line
• Bone loss in a rat model of non-insulin-dependent diabetes mellitus,the OLETF(Otsuka Long-Evans Tokushima fatty strain)rat
• 閉経期日本人女性における腰椎骨密度の5年間の減少に対する関連因子
• 女子大学生の低血圧と保健行動
• Omental Cyst : Report of a Case
• VI 道喜美代 栄養学の研究を貫いて第八代学長へ
• カルシウム摂取の現状(欧米とわが国の現状) (特集 栄養と骨粗鬆症)
• 発育期ラットの骨密度に対する食餌性カルシウム量の影響 (第4回日本骨粗鬆症学会 一般演題Highlight)
• 骨と健康
• 卵巣摘出骨粗鬆症モデルラットの骨量増加に対するラクトースの効果 (第3回日本骨粗鬆症学会)
• カルシウム素材の吸収性と吸収促進法 (特集 ミネラルの作用と利用)
• 何が今の家政学の抱える問題か : 食物領域の研究・教育の現状から(共通テーマ報告,新しい千年紀に立って家政学を考える,2001年家政学原論部会夏期セミナー)
• 間違ったダイエットの骨への影響(暮らしと安全 25)
• 3. 妊娠ラットのカルシウム出納および骨密度の変化に関する検討
• 成長期ラットの骨形成能に対する自由運動およびエネルギー摂取の効果
• 成長期ラットの骨形成能に対する自由行動およびエネルギー摂取の効果
• 発育期ラットの骨量増加に対する自由運動の効果
• ミネラル代謝に関わる栄養学
• Selective α-Glucosylation of Eugenol by α-Glucosyl Transfer Enzyme of Xanthomonas campestris WU-9701(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
• Interaction between mesothelial cells and macrophages in the initial process of pleural adhesion : ultrastructural studies using adhesion molecules
• Neutrophilic involvement in the damage to coronary arteries in acute stage of Kawasaki disease
• Intestinal bacteria-derived putrefactants in chronic renal failure
• Regulation of parathyroid function in chronic kidney disease (CKD)
• Fluo-3 as an Extracellular Ca^ Indicator : Warning on the Use of the Dye for Slice Preparations
• A case of Adenoid Cystic Carcinoma (ACC) of the Breast and Review of the Utility of Preoperative Imaging Diagnose
• A Novel Labdane-Type Trialdehyde from Myoga (Zingiber mioga Roscoe) That Potently Inhibits Human Platelet Aggregation and Human 5-Lipoxygenase
• Antimicrobial Activities of Diterpene Dialdehydes, Constituents from Myoga (Zingiber mioga Roscoe), and Their Quantitative Analysis
• Labdane-type Diterpene Dialdehyde, Pungent Principle of Myoga, Zingiber mioga Roscoe(Food & Nutrition Science)
• evidence-based practice guideline for the treatment of chronic kidney disease
• Rare Gas Metastable Atom Density in Diluted O_2 RF Plasmas
• Menatetrenone Ameliorates Reduction in Bone Mineral Density and Bone Strength in Sciatic Neurectomized Rats
• A Possible Role of Thioredoxin Interacting Protein in the Pathogenesis of Streptozotocin-induced Diabetic Nephropathy
• PJ-657 Asymmetric Dimethylarginine (ADMA) is an Incipient Marker of Arteriosclerosis in Kidney and Heart(Kidney/Renal circulation-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Administration of human immunoglobulin suppresses development of murine systemic vasculitis induced with Candida albicans water-soluble fraction : an animal model of Kawasaki disease
• Uremic toxin and bone metabolism
• Combination use of vitamin K_2 further increases bone volume and ameliorates extremely low turnover bone induced by bisphosphonate therapy in tail-suspension rats
• Menatetrenone Prevents Osteoblast Dysfunction in Unilateral Sciatic Neurectomized Rats
• Maintenance of trabecular structure and bone volume by vitamin K_2 in mature rats with long-term tail suspension
• Measurements of blood DMSO and DMSO_2 in a healthy person and a hemodialysis patient
• The kidney and bone metabolism : Nephrologists' point of view
• Calcium abnormalities of dialysis patients
• Ever-Changing Concepts of Calciphylaxis
• リコピン摂取が発育期雄ラットの走行トレーニングによる骨塩量増加に及ぼす効果
• Occurrence of Stereoisomers of 1-(2'-Pyrrolidinethione-3'-yl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic Acid in Fermented Radish Roots and Their Different Mutagenic Properties
• Parathyroid hormone increases the expression level of matrix metalloproteinase-13 in vivo
• Implementation of Steady-State Suppression Using a Digital Signal Processor for Real-Time Processing--Evaluation of the Processing in an Actual Hall (国際ワークショップ Frontiers in Speech and Hearing Research)
• Abnormal Formation of Fibrin Network from X-ray Irradiated Fibrinogen : Two-color Fluorescence Analysis of the Dynamic Process and the Incorporation of Fibrinolytic Components into Fibrin by Confocal Laser-Scanning Microscopy
• Comparison of the Nicotinamide Catabolism among Rat Strains
• Mioganal, a Novel Pungent Principle in Myoga (Zingiber mioga Roscoe) and a Quantitative Evaluation of Its Pungency
• OJ-260 The effect of oral charcoal adsorbent (AST-120) on the progression of cardiac abnormalitites in chronic kidney disease(OJ44,Kidney/Renal Circulation/CKD 2 (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulati
• Change in Calcium Balance and Bone Mineral Density during Pregnancy in Female Rats
• The Effect of Swimming on Cartilage Formation
• Estrogen deficiency and low-calcium diet increased bone loss and urinary calcium excretion but did not alter arterial stiffness in young female rats
• Effect of 1α-hydroxyvitamin D_3 and egg-shell calcium on bone metabolism in ovariectomized osteoporotic model rats
• Oral carbonaceous absorbent modifies renal function of renal ablation model without affecting plasma renin-angiotensin system or protein intake
• Fluorometric determination of pantothenic acid in human urine by isocratic reversed-phase ion-pair high-performance liquid chromatography with post-column derivatization
• レンズレス光フロッピーディスクヘッドによる静止系記録・再生実験
• A CONVENIENT METHOD FOR GENOTYPING OF HUMAN O^6-METHYLGUANINE-DNA METHYLTRANSFERASE POLYMORPHISM
• COMPARISON OF ULTRAFLEX AND NITI-S STENTS FOR PALLIATION OF UNRESECTABLE MALIGNANT GASTRODUODENAL OBSTRUCTION
• Effects of Physical Characteristics and Dietary Habits on Bone Mineral Density in Adolescent Girls
• Modulation of Bone Mass and Turnover in Growing Rats by Voluntary Weight-Bearing Exercise and Glucose Supplementation
• Effects of Ovariectomy on Intestinal Alkaline Phosphatase Expression in Rats
• Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)
• Effect of Long-Term Alcohol Administration on Bone Metabolism in Rats
• A Half-Century of Autopsy Results : Incidence of Pediatric Vasculitis Syndromes, Especially Kawasaki Disease
• A Case of Slowly Progressive Type 1 Diabetes with Insulin Independence Maintained for 10 Years with α-glucosidase Inhibitor Monotherapy
• Diseases of the parathyroid gland in chronic kidney disease
• Menatetrenone Ameliorates Reduction in Bone Mineral Density and Bone Strength in Sciatic Neurectomized Rats
• Effects of Liraglutide, a Human Glucagon-like Peptide-1 Analogue, on Body Weight, Body Fat Area and Body Fat-related Markers in Patients with Type 2 Diabetes Mellitus
• Ovariectomy Decreases Osteogenetic Activity in Rat Bone.
• The Effect of Swimming on Cartilage Formation.
• Effect of Vitamin D Metabolites on Bone Metabolism in a Rat Model of Postmenopausal Osteoporosis
• The Nutritional Evaluation of Globin on Maintenance of Bone Metabolism in Ovariectomized Osteoporotic Rats.
• The Effect of Milk and Skim Milk Intake on Serum Lipids and Apoproteins in Postmenopausal Females.
• The Effect of Tochu Bark on Bone Metabolism in the Rat Model with Ovariectomized Osteoporosis.
• The Effect of Spiny Lobster Shell Powder on Bone Metabolism in Ovariectomized Osteoporotic Model Rats.
• Cross-Sectional and Longitudinal Studies on the Effect of Water Exercise in Controlling Bone Loss in Japanese Postmenopausal Women.
• Renal disease in the elderly and the very elderly Japanese : analysis of the Japan Renal Biopsy Registry (J-RBR)
• The onset of antineutrophil cytoplasmic antibody-associated vasculitis immediately after methimazole was switched to propylthiouracil in a woman with Graves' disease who wished to become pregnant
• The Relationship between Salivary Calcium Concentration and Differences in Bone Mineral Density Level in Female Rats

もっと見る 閉じる

スポンサーリンク