Effects of Ovariectomy on Intestinal Alkaline Phosphatase Expression in Rats

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概要

• 論文の詳細を見る

• The aim of this study was to investigate the effects of ovariectomy (OVX) on intestinal alkaline phosphatase (ALP) activity in rats. The calcium (Ca) and phosphorus (P) contents and the mechanical strength of bone were decreased significantly by OVX. Two kinds of mRNAs of rat intestinal ALP (RTIN-1 and RTIN-2) were detected by reverse transcription-polymerase chain reaction (RT-PCR). In OVX rats, the level of RTIN-2 mRNA was lowered significantly, while that of RTIN-1 mRNA did not change. This result was compatible with the results of enzymatic activity. This finding suggests the possibility that OVX affects bone metabolism not only directly but also in an indirect way through an intestinal Ca and/or P metabolism via regulation of intestinal RTIN-2 ALP expression.

• 財団法人 学会誌刊行センターの論文

著者

• Sasaki Satoshi

  Department Of Internal Medicine And Molecular Science Nagoya City University Graduate School Of Medi

• MATSUMOTO Hiroko

  Department of Bioscience and Biotechnology, Division of Bioresource and Bioenvironmental Sciences, G

• Ezawa Ikuko

  Department Of Food And Nutrition Japan Women's University

• Goseki-sone Masae

  Department Of Food And Nutrition Japan Women's University

• Oida Shinichiro

  Department Of Biochemistry Faculty Of Dentistry Tokyo Medical And Dental University

• Imura Tadahiro

  Department Of Molecular Craniofacial Embryology Graduate School Tokyo Medical And Dental University

• Yamamoto Asako

  Department Of Pediatrics Yamato City Hospital

• IIMURA Tadahiro

  Department of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental Universit

• Sasaki Satoshi

  Department Of Biochemistry School Of Dentistry Tokyo Medical And Dental University

• Sasaki Satoshi

  Department Of Applied Physics Faculty Of Engineering Nagoya University

• Matsumoto Hiroko

  Department Of Astronomy School Of Science Kyoto University

• IIMURA Tadahiro

  Department of Biochemistry, Faculty of Dentistry, Tokyo Medical

• YAMAMOTO Asako

  Department of Food and Nutrition, Japan Women's University

• GOSEKI-SONE Masae

  Department of Biochemistry, Faculty of Dentistry, Tokyo Medical

• MATSUMOTO Hiroko

  Department of Food and Nutrition, Japan Women's University

• OIDA Shinichiro

  Department of Biochemistry, Faculty of Dentistry, Tokyo Medical

• EZAWA Ikuko

  Department of Biochemistry, Faculty of Dentistry, Tokyo Medical and Dental University

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