Menatetrenone Prevents Osteoblast Dysfunction in Unilateral Sciatic Neurectomized Rats

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概要

• 論文の詳細を見る

• Menatetrenone (MK-4) inhibits bone resorption and enhances osteoblast-induced mineralization. In this study, we examined whether MK-4 administration had beneficial effects on osteoblast dysfunction and trabecular microstructure as well as on bone volume loss in a rat model of osteopenia. Male Sprague-Dawley rats were neurectomized and administered MK-4 as a daily supplement. On Day 21 after neurectomy, significant bone loss was observed in the positive control rats. MK-4 prevented the decrease in bone mineral density of the distal metaphysis of the femur. The osteoclast surface per bone surface (Oc.S/BS) and the number of osteoclasts per bone perimeter (N.Oc/B.Pm) were reduced and the mineral apposition rate (MAR) decreased in the immobilized rats on Day 42, suggesting suppression of bone turnover. In contrast, administration with a low dose of menatetrenone led to an increase of MAR and bone formation rate (BFR), while Oc.S/BS and N.Oc/B.Pm remained at normal levels. These data suggested that MK-4 reduced the loss of trabecular bone, prevented osteoblast dysfunction to a certain extent, and contributed to preservation of the trabecular microstructure in this rat model of osteopenia induced by sciatic neurectomy.

• 社団法人 日本薬理学会の論文
• 2002-09-01

著者

• FUKAGAWA Masafumi

  Division of Nephrology and Kidney Center, Kobe University School of Medicine

• Fukagawa Masafumi

  大分県立看護科学大学

• Fukagawa Masafumi

  Division Of Nephrology And Dialysis Center Kobe University School Of Medicine

• KUROKAWA Kiyoshi

  Division of Nephrology and Metabolism, Department of Internal Medicine

• EZAWA Ikuko

  Department of Food and Nutrition,School of Home Economics,Japan Women's University

• Ezawa I

  Japan Women's Univ. Tokyo Jpn

• Ezawa Ikuko

  Department Of Food And Nutrition Japan Women's University

• Ezawa Ikuko

  Graduate School Of Human Life Science Japan Women's University

• Fukagawa Masafumi

  Division Of Nephrology And Dialysis Center Kobe University Graduate School

• YAMATO Hideyuki

  Biomedical Research Laboratories, Kureha Chemical Ind. Ltd.

• MURAYAMA Hisashi

  Biomedical Research Laboratories, Kureha Chemical Ind. Ltd.

• Yamato Hideyuki

  Division Of Development Kureha Special Laboratory

• IWASAKI YOSHIKO

  Division of Nephrology and Endocrinology, University of Tokyo School of Medicine

• TAKAHASHI TAKESHI

  Division of Nephrology and Clinical Research Center, Tokyo Teishin Hospital

• Hiroshi Yamagiwa

  Division Of Orthopedic Surgery Department Of Regenerative And Transplant Medicine Niigata University

• Kurokawa K

  Research Center For Advanced Science And Technology Of The University Of Tokyo

• Fukagawa M

  Division Of Nephrology And Dialysis Center Kobe University School Of Medicine

• Yamato Hideyuki

  Biomedical Research Laboratories Kureha Chemical Co. Ltd.

• Iwasaki Yoshiko

  Department Of Health Sciences Oita University Of Nursing And Health Sciences

• Murayama Hisashi

  Biomedical Research Laboratories Kureha Chemical Ind. Ltd.

• Yamagiwa Hiroshi

  Dapartment Of Orthopaedic Surgery Niigata University School Of Medicine

• Yamagiwa Hiroshi

  Division Of Orthopedic Surgery Department Of Regenerative And Transplant Medicine Niigata University

• Takahashi Takeshi

  Division Of Nephrology And Clinical Research Center Tokyo Teishin Hospital

• Takahashi Takeshi

  Division Of General Education Nagaoka National College Of Technology

• Kurokawa Kiyoshi

  Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai University

• Iwasaki Yoshiko

  Division of Nephrology and Clinical Research Center, Tokyo Teishin Hospital

• EZAWA Ikuko

  Department of Biochemistry, Faculty of Dentistry, Tokyo Medical and Dental University

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