Effect of Organic Germanium Compound (Ge-132) on Experimental Osteoporosis in Rats: The Relationship Between Transverse Strength and Bone Mineral Density (BMD) or Bone Mineral Content (BMC)

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概要

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• The antiosteoporotic effect of organic germanium compound, poly-trans-(2-carboxyethyl)germaniumsesquioxide (Ge-132), was studied using ovariectomized rats maintained on a low calcium diet. Rats without ovariectomy and maintained on a normal commercial diet gave the highest femur transverse strength as well as the highest BMD or BMC, measured by peripheral quantitative computed tomography (pQCT) of the femur bone. A daily dose of 18 mg/kg gave the highest femur transverse strength among the dose schedules of 0, 0.5, 3.0, 18.0, and 108.0 mg/kg/day, after both 3 and 6 months in ovariectomized rats maintained on a low calcium diet. Morphological analysis of the femur, especially weight and outside diameter also supported that Ge-132 enhances the femur transverse strength. The pQCT measurements of the femur demonstrated that a high correlation existed between the transverse strength and total BMD or BMC.

• 日本大学の論文

著者

• Fujii Akira

  Department of Cardiology, Ehime National Hospital

• Hashimoto Takafumi

  Department of Cardiology, Musashino Red Cross Hospital

• Fujii Akira

  Department Of Oral Molecular Pharmacology Nihon University School Of Dentistry At Matsudo

• MATSUMOTO Hiroko

  Department of Bioscience and Biotechnology, Division of Bioresource and Bioenvironmental Sciences, G

• Nonaka Kiichi

  Woman's Healthcare Div. Elkc Co.

• Hashimoto Takafumi

  Department Of Pharmacology Nihon University School Of Dentistry At Matsudo:(present Address)departme

• Fujii A

  Yukawa Institute For Theoretical Physics Kyoto University

• FUJII Akira

  Yukawa Institute for Theoretical Physics, Kyoto University

• KUBOYAMA Noboru

  Department of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo

• Kuboyama Noboru

  Department Of Oral Molecular Pharmacology Nihon University School Of Dentistry At Matsudo

• Kuboyama Noboru

  Department Of Pharmacology Nihon University School Of Dentistry At Matsudo

• Hashimoto Takafumi

  Department Of Cardiology Musashino Red Cross Hospital

• Jiang Gui-Zhen

  Department of Pharmacology, Nihon University School of Dentistry at Matsudo,

• Yamane Junichi

  Department of Pharmacology, Nihon University School of Dentistry at Matsudo,

• Jiang Gui-zhen

  Department Of Oral Molecular Pharmacology Nihon University School Of Dentistry At Matsudo

• Yamane Junichi

  Department Of Pharmacology Nihon University School Of Dentistry At Matsudo

• Jiang Guizhen

  Department Of Pharmacology Nihon University School Of Dentistry At Matsudo

• Fujii Akira

  Department Of Applied Chemistry Faculty Of Engineering Oita University

• Matsumoto Hiroko

  Department Of Oral Molecular Pharmacology Nihon University School Of Dentistry At Matsudo

• Matsumoto Hiroko

  Department Of Astronomy School Of Science Kyoto University

• Fujii Akira

  Department of Clinical Pharmacology, Nihon University School of Dentistry at Matsudo

• Kuboyama Noboru

  Department of Pharmacology, Nihon University School of Dentistry at Matsudo,

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