The effect of IL-l.ALPHA. and nifedipine of cell proliferation and DNA synthesis in cultured human gingival fibroblasts
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概要
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The effect of nifedipine and interleukin-α (IL-1α) on the cell proliferation and DNA synthesis was studied in human gingival fibroblasts derived from 5 patients who developed gingival overgrowth (nifedipine responders) and 5 patients who did not develop gingival overgrowth (nifedipine non-responders) in response to nifedipine. Epidermal growth factor was used as a positive control. The fibroblasts derived from nifedipine responders tended to have a numerically greater rate of cell proliferation and DNA synthesis (<Sup>3</Sup>H-thymidine incorporation) than those from nifedipine non-responders in the presence of nifedipine and IL-1α. Fibroblasts derived from nifedipine responders showed significantly higher cell proliferation rate in the presence of nifedipine and IL-1α, than nifedipine or IL-1α alone on both the second and the fourth day of incubation (<I>P</I> < 0.05). A combination of IL-1α and epidermal growth factor also showed significantly greater cell proliferation than IL-1α alone on the second day (<I>P</I> < 0.05). The DNA synthesis rate with a combination of nifedipine and IL-1α was higher than that for nifedipine alone on the second day (<I>P</I> < 0.01), and IL-1α alone on the fourth day (<I>P</I> < 0.05) in gingival fibroblasts originating from nifedipine responders. These results suggest that the interaction between nifedipine and gingival inflammation might play an important role in the pathogenesis of nifedipine-induced gingival overgrowth. (J. Oral Sci. 47, 105-110, 2005)
著者
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Sato Naoto
Department Of Biological Sciences Graduate School Of Science University Of Tokyo
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Fujii Akira
Department Of Applied Chemistry Faculty Of Engineering Oita University
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Matsumoto Hiroko
Department Of Astronomy School Of Science Kyoto University
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Akimoto Yoshiaki
Department of Dento-Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo
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