Augmentation of wound healing by royal jelly(RJ) in streptozotocin-diabetic rats.
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概要
- 論文の詳細を見る
Chronically diabetic rats prepared by a single i.v. Injection of streptozotocin were used to study whether royal jelly (RJ) possesses a hypoglycemic reaction and whether it can augment wound healing. Oral RJ administration of 10, 100 and 1000 mg/kg/day did not show any insulin-like activity (the hypoglycemic reaction). RJ, however, showed some anti-inflammatory activity by decreasing exudation and collagen formation in granulation tissue formation in the cotton pellet method. RJ also shortened the healing period of desquamated skin lesions. Thus, RJ possesses an anti-inflammatory action and is able to augment wound healing, but does not have an insulin-like action in streptozotocin-diabetic rats.
- 公益社団法人 日本薬理学会の論文
著者
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Kaneko Yoshiaki
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical College
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Kuboyama Noboru
Department Of Oral Molecular Pharmacology Nihon University School Of Dentistry At Matsudo
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Fujii Akira
Department Of Applied Chemistry Faculty Of Engineering Oita University
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Furukawa Yoko
Department Of Health And Nutrition Faculty Of Health Science Kyoto Koka Women's University
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KOBAYASHI Sumi
Department of Pharmacology, Nihon University School of Dentistry
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ISHIHAMA Seimi
Department of Pharmacology, Nihon University School of Dentistry
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YAMAMOTO Hirotugu
Department of Pathology, Nihon University School of Dentistry
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TAMURA Toyoyuki
Research Institute of Sciences, Nihon University
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FURUKAWA Yoko
Department of Pharmacology, Nihon University School of Dentistry
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KUBOYAMA Noboru
Department of Pharmacology, Nihon University School of Dentistry
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