QT Interval Prolongation and Torsade de Pointes Induced by Propofol and Hypoalbuminemia
スポンサーリンク
概要
- 論文の詳細を見る
We report the case of a 70-year-old man presenting with the development of torsade de pointes (TDP) during infusion of propofol in the setting of severe hypoalbuminemia. TDP developed 15 hours after the beginning of a standard infusion of propofol, following the development of a prominent U wave and prolongation of the QTc interval. While the serum concentrations of electrolytes were within normal ranges, serum albumin as low as 1.4 mg/dL was observed. TDP disappeared during the infusion of isoproterenol, and QTc normalized after the discontinuation of propofol. We hypothesize that hypoalbuminemia increased the free fraction of propofol, causing marked QTc prolongation and TDP.
著者
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Irie Tadanobu
Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine
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Kaneko Yoshiaki
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical College
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Kurabayashi Masahiko
Department Of Cardiology Kanazawa Medical University
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Nakajima Tadashi
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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Saito Akihiro
Department Of Applied Biology And Chemistry Faculty Of Applied Bio-science Tokyo University Of Agric
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