Post Myocardial Ischemia-Associated Torsades De Pointes in a Patient Carrying a KCNQ1 G643S Variant

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概要

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• Polymorphic ventricular tachycardia, which occurs during the subacute phase of myocardial infarction (MI) or ischemia and is not related to ongoing ischemia, has recently been reported. It has characteristics of typical pause-dependent torsades de pointes (TdP) following excessive QT prolongation (post MI/ischemia-associated TdP). We describe a male patient with post MI/ischemia-associated TdP. The patient experienced recurrent TdP with excessive QT prolongation 2 days after transient myocardial ischemia. Genetic screening of the major LQTS-causing genes identified a KCNQ1 G643S variant. This gene variant could be a genetic predisposition to the development of TdP during the subacute phase of MI/ischemia.

著者

• Irie Tadanobu

  Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine

• Kato Toshimitsu

  Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine

• Kaneko Yoshiaki

  Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical College

• Iso Tatsuya

  Department Of Medicine And Biological Science

• Kurabayashi Masahiko

  Department Of Cardiology Kanazawa Medical University

• Nakajima Tadashi

  Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University

• Saito Akihiro

  Department Of Applied Biology And Chemistry Faculty Of Applied Bio-science Tokyo University Of Agric

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