Time-course study of gastric damages in rats by anti-inflammatory drugs using a gastroscope and its quantification.
スポンサーリンク
概要
- 論文の詳細を見る
Time-course studies on gastric damages in rats caused by nonsteroidal anti-inflammatory drugs (NSAIDs) were performed using a gastroscope, and the readings were quantified to obtain the Congestion-Hemorrhage Index (CHI) for evaluating the potencies of the damaging properties of NSAID. The correlation between CHI and Ulcer Index (UI), the quantified value obtained by the conventional methods, was highly significant at 6 and 24 hr after forced oral administration of NSAID. The peak CHIs of aspirin (300 mg/kg), indomethacin (60 mg/kg), mefenamic acid (300 mg/kg) and fenoprofen calcium (300 mg/kg) appeared approximately 24 hr after a single forced oral administration of drugs. Thus, it was suggested that an observation at 24 hr in addition to one at 6 to 7 hr might be necessary for the examination of damaged gastric mucosa. Under the present experimental conditions, fenoprofen calcium caused the greatest damages on gastric mucosa among the four NSAIDs. Mefenamic acid showed the least damaging potency on gastric mucosa, having a smaller CHI than that of aspirin. Indomethacin possessed a stronger damaging property than aspirin.
- 公益社団法人 日本薬理学会の論文
著者
-
KOBAYASHI Sumi
Department of Pharmacology, Nihon University School of Dentistry at Matsudo
-
Kuboyama Noboru
Department Of Oral Molecular Pharmacology Nihon University School Of Dentistry At Matsudo
-
Tamura Toyoyuki
Department Of Pharmacology Nihon University School Of Dentistry At Matsudo
-
Fujii Akira
Department Of Applied Chemistry Faculty Of Engineering Oita University
-
KOBAYASHI Sumi
Department of Pharmacology, Nihon University School of Dentistry
-
NAMIKI Yoshikazu
Department of Pharmacology, Nihon University School of Dentistry at Matsudo
関連論文
- PE-310 Impaired Postprandial Vasodilatation in Metabolic Syndrome. On behalf of MEAL Investigators.(Diabetes/Obesity/Metabolic syndrome(06)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- An Unusually Large Submandibular Salivary Calculus: Case Report and Structural Analysis
- Midline cystic malformations of the brain : imaging diagnosis and classification based on embryologic analysis
- Fluorescent In Situ Hybridization Analysis of Open Lactic Acid Fermentation of Kitchen Refuse Using rRNA-Targeted Oligonucleotide Probes(ENVIRONMENTAL BIOTECHNOLOGY)
- Comparative antimutagenicity of saliva and oral bacteria against mutagens
- AED Location in Public Spaces : A Case Study in Ueno Park Using Voronoi Diagrams with Obstacles(Architectural/Urban Planning and Design)
- Osteosarcoma of the mandible in an aged person
- Diagnostic Problems of Early and Primary Lesions of Tuberculous Cervical Lymphadenitis
- Elevated levels of oxidized low density lipoprotein (ox-LDL) relate to plaque instability in diabetic patients
- Intermittent Crystal Growth of Unusually Long Submandibular Sialolith Revealed by Micro-Focus-and Selected-Area-X-Ray Diffraction
- DELETERIOUS EFFECT OF SHORT-TERM EXPOSURE TO COCA-COLA ON RATS
- 101. STUDY ON TOXICITY OF COCA-COLA (The Third Meeting for the Study of Toxic Effect)
- FETAL LIVER AND KIDNEY TOXICITIES BY ALCOHOL AND SUCROSE
- INFLUENCE OF SUGAR ON THE STRENGTH OF RAT FEMUR BONE
- Experimental Study of Bone Formation Ability with the Periosteum on Rat Calvaria
- Drug-induced gingival overgrowth and its tentative pharmacotherapy
- Effect of Organic Germanium Compound (Ge-132) on Experimental Osteoporosis in Rats: The Relationship Between Transverse Strength and Bone Mineral Density (BMD) or Bone Mineral Content (BMC)
- Differences of Cell Growth and Cell Cycle Regulators Induced by Basic Fibroblast Growth Factor Between Nifedipine Responders and Non-responders
- Correlation among geometric, densitometric, and mechanical properties in mandible and femur of osteoporotic rats
- Mandible bone loss in osteoporosis rats
- SUSCEPTIBILITY OF SWISS ALBINO MICE TO Staphylococcus aureus INFECTIONS UNDER LEAD ACETATE INFLUENCES AND THE PROTECTIVE ACTION OF YEAST EXTRACTS TO THE INFECTION (The Fourth Meeting for the Study of Toxic Effect)
- Effect of Low Level Laser Irradiation on CXCR3 Gene Expression in Rheumatoid Arthritis Joint
- Syntactic and Network Pattern Structures of City : Comparison of Grid and Meandering Street Patterns in Kyojima and Honjo(Architectural/Urban Planning and Design)
- Possibility of application of calcium carbonate in pulpotomy of rat molars
- Prevention of trabecular bone loss in the mandible of ovariectomized rats
- Influence of aging on experimental gastrointestinal motility in extraction of rat molar teeth
- Stimulation of Mesenchymal-epithelial Transition Factor (c-Met) Expression in Candida Albicans-infected Human Gingival Epithelial Cells and Rat Gingival Epithelium
- The effect of IL-l.ALPHA. and nifedipine of cell proliferation and DNA synthesis in cultured human gingival fibroblasts
- Augmentation of wound healing by royal jelly(RJ) in streptozotocin-diabetic rats.
- Time-course study of gastric damages in rats by anti-inflammatory drugs using a gastroscope and its quantification.
- Healing-promoting action of dried aluminium hydroxide gel evaluated by the method of histological measurements in acetic acid ulcer of rats.
- Healing-promoting action of teprenone, a new antiulcer agent on acetic acid ulcer in rats.