Recurrent Solitary Fibrous Tumor of the Pleura with Malignant Transformation and Non-islet Cell Tumor-induced Hypoglycemia due to Paraneoplastic Overexpression and Secretion of High-molecular-weight Insulin-like Growth Factor II
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概要
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A 41-year-old man was diagnosed with a solitary fibrous tumor (SFT) of the pleura in the posterior mediastinum. Despite two surgeries for excision, the SFT recurred and progressed with direct invasion of the chest wall and bone metastases. He was hospitalized because of cerebral infarction and presented with recurrent severe hypoglycemia fourteen years later. High-molecular-weight (HMW) insulin-like growth factor II (IGF-II) was identified in the serum and tumor using Western blotting and immunohistochemistry. These findings suggested that the cause of the recurrent severe hypoglycemia was SFT production of HMW IGF-II, a mediator of non-islet cell tumor-induced hypoglycemia (NICTH).
著者
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Sugino Keishi
Department Of Respiratory Medicine Toho University Medical Center
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Uekusa Toshimasa
Department Of Laboratory Medicine Kanto Rousai Hospital
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Fukuda Izumi
Department Of Chemistry Faculty Of Science And Engineering Saga University
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Aiba Motohiko
Department Of Pathology School Of Medicine Keio University
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Hatanaka Kazuhito
Department Of Forensic Medicine Graduate School Of Medicine University Of Tokyo
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HIZUKA NAOMI
Department of Internal Medicine Tokyo Women's Medical College
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Yokochi Akio
Division of Nephrology and Metabolism, Kanto Rosai Hospital, Japan
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Tominaga Naoto
Division of Nephrology and Metabolism, Kanto Rosai Hospital, Japan
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Kawarasaki Chiaki
Division of Nephrology and Metabolism, Kanto Rosai Hospital, Japan
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Kanemoto Keiko
Division of Nephrology and Metabolism, Kanto Rosai Hospital, Japan
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Uda Susumu
Division of Nephrology and Metabolism, Kanto Rosai Hospital, Japan
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Fukuda Izumi
Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University, Japan
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