Pharmacodynamic and pharmacological effects of MPC-1304, a new calcium channel blocker, in healthy subjects. Results of multiple oral administration.:Results of Multiple Oral Administration

スポンサーリンク

概要

• 論文の詳細を見る

• The pharmacodynamic and pharmacological effects of MPC-1304 after multiple oral administration were studied in a cross-over double-blind fashion with sustained release formulation of nifedipine (10 mg Sepamit<SUP>®</SUP> capsule) as reference drug, using 16 healthy adult male volunteers. They received 10 mg of MPC-1304 (once or twice a day) and 20 mg of nifedipine (twice a day) for 7 days.<BR>Pharmacokinetics of MPC-1304 were assessed by measuring plasma and urine concentrations of MPC-1304 itself and its metabolites. After multiple administration of MPC-1304, plasma concentrations of MPC-1304 itself and MPC-1304-keto-H<SUB>2</SUB>, the active metabolite, reached its plateau in 2 days and remained stable during the rest of the study.<BR>The calculated pharmacokinetic parameters on the seventh day were almost the same as those on the first day and were not so different from those of the single-dose study.<BR>The percent excretion ratio of MPC-1304 and its metabolites in 24-hr urine was not affected by multiple administration.<BR>These results suggested that neither accumulation nor significant change of pharmacokinetics was observed in the plasma levels of metabolites even after multiple administration of MPC-1304.<BR>Blood pressure did not change significantly both after MPC-1304 and nifedipine, though heart rate was transiently increased.<BR>Following multiple administration of MPC-1304 and nifedipine, subjects complained of headache and dull-headedness but all of these were transient and tolerable. Notable abnormalities were not observed in laboratory findings during the study and so there was not significant difference for adverse effects between two drugs.<BR>In conclusion, MPC-1304 can be expected to be a safe calcium channel blocker with hypotensive effect.

• 一般社団法人 日本臨床薬理学会の論文

著者

• 海老原 昭夫

  大分医科大学医学部臨床薬理学

• 中島 創

  大分医科大学医学部臨床薬理学

• 大橋 京一

  自治医科大学臨床薬理学教室

• 熊谷 雄治

  大分医科大学臨床薬理学教室

• 川島 紘一郎

  共立薬科大学薬理

• 杉本 孝一

  大分医科大学臨床薬理

• 織部 尚利

  大分医科大学臨床薬理

• 市東 哲夫

  大分医科大学臨床薬理

• 山上 久

  久仁会鳴門山上病院

• 熊谷 雄治

  大分医科大学臨床薬理

• 織部 尚利

  大分医科大学内科第一

• 大橋 京一

  自治医科大学臨床薬理

関連論文

• 健常成人におけるバルプロ酸反復投与時の体内動態
• 卵巣癌患者におけるPaclitaxelの骨髄抑制自験例でのCAP療法・JP療法との比較
• 大分医科大学における臨床試験ワーキンググループ活動の紹介
• 大分医科大学医学部附属病院における治験に参加した被験者に関する調査
• ヒスタミンH_2受容体遮断薬
• 哺乳動物における非神経性アセチルコリンの発現とその生理作用
• 自戒
• 研究と新薬開発のターゲットとしてのリンパ球におけるコリン作動系
• 循環器薬に関連した相互作用(高齢者に繁用される薬剤の相互作用)
• Dosage regimen for ranitidin in renal impairment. (2). Multiple oral dose studies.
• A compartment model for a sustained release preparation with zero-order release.
• Effect of diltiazem and cimetidine on the metabolism of Propranolol.
• Pharmacokinetics of beta-methyldigoxin. Comparison between the results by FPIA method and the results by post-separation assay method.
• Assessment of a simple method for acetylator phenotyping with caffeine.
• Polymorphous mode of caffeine metabolism in the Japanese poeple. On genotypes.
• Pharmacokinetics, pharmacodynamics, and safety of bevantolol, a new .BETA.1-selective .BETA.-adrenoceptor antagonist, in Japanese healthy volunteers.
• Clinical pharmacological studies on a new .BETA.1 selective .BETA.-blocker, bevantolol.
• Population pharmacokinetics of theophylline in patients with infantile bronchial asthma.
• Clinical pharmacology of ibopamine. (1). Safety and pharmacological actions after single and multiple oral doses in Japanese healthy subjects.
• TDM of Digoxin and .BETA.-Methyldigoxin.
• Pharmacokinetics of beta-methyldigoxin.
• Clinical pharmacology of nitrendipine - Single- and multiple-dose study in Japanese healthy subjects.:Single- and Multiple-Dose Study in Japanese Healthy Subjects
• Pharmacokinetics of ketoprofen sustained-releasing preparation (RPY-001) in Japanese normal adult persons.
• Pharmacodynamic and pharmacological effects of nipradilol (K-351) in healthy volunteers. Comparison with propranolol.:Comparison with Propranolol
• Influence of beta-adrenergic blocking agent on the circadian rhythm of blood pressure in patients with essential hypertension.
• Pharmacodynamics and pharmacological action in essential hypertension patient of calcium antagonist CS-905.
• Clinical phase I studies of a new antiemetic drug, SN-307 (ondansetron).
• タイトル無し
• Pharmacokinetics of digoxin in patients with duchenne muscular dystrophy.
• Dosage regimen for ranitidine in renal impairment.
• Effects of prazosin and urapidil on the fingertip skin blood flow under cold exposure.
• 新しいヒスタミンH_2受容体遮断薬 Ranitidine の臨床薬理学的検討
• Clinic phase I study of migraine drug sumatriptan(SN-308).Single and repetitive subcutaneous injection test.
• タイトル無し
• Effect of cimetidine, diltiazem on oxidative metabolism of theophylline.
• Effect of diltiazem on the pharmacodynamics of Ca antagonist, MPC-1304.
• Influence of diltiazem on antipyrine and trimethadione.
• Effect of premedication term and premedication dose of diltiazem on pharmacokinetics of nifedipine.
• Effect of diltiazem on pharmacokinetics of theophylline.
• Pharmacodynamics and pharmacological actions of MPC-1304, a Ca antagonist, in healthy adults.
• Effects of angiotensin II converting enzyme inhibitor enarapril on autonomic nervous system.
• Pharmacodynamic and pharmacological effects of MPC-1304, a new calcium channel blocker, in healthy subjects. Results of multiple oral administration.:Results of Multiple Oral Administration
• Effect of Food and Gastric Acidity on the Pharmacokinetics of MPC-1304, a New Calcium Channel Blocker.
• Effects of MPC-1304 on blood flow of the finger tip.
• Pharmacokinetics and pharmacodynamic effects of sustained release formulation of urapidil (BKU) in healthy subjects. Results of repeated oral administration.:Results of Repeated Oral Administration
• Effect of ranitidine on urinary excretion by furosemide.
• タイトル無し
• Clinical pharmacology of a new antiplatelet drug, KBT-3022. Results of single administration in Japanese healthy adults.
• 甲状腺機能充進症および低下症における脂質代謝に関する臨床的研究:治療前後におけるアポ蛋白の検討
• Clinical pharmacology of a new antiplatelet drug, KBT-3022. Studies on repeated administration in healthy adults.
• Effect of beta-blockers on circadian rhythm of blood pressure in patients with essential hypertension.
• Clinical pharmacology of ibopamine. (2). Pharmacokinetics after single and multiple oral administration in healthy Japanese subjects.
• Circadian variation in blood pressure in case of administration of various types of hypotensive drugs.
• Effects of ageing on liver metabolism of Propranolol.On oxidation, and conjugation reaction.
• Pharmacodynamics of beta-methyldigoxin in renal dialysis patient.
• タイトル無し
• Pharmacodynamic and pharmacological effects of MPC-1304, a new calcium channel blocker, in healthy subjects. Results of single oral administration.:Results of Single Oral Administration
• Pharmacokinetirs of diltiazem in patients with paroxysmal supraventricular tachycardia.
• Various types of caffeine metabolism in Japanese people. Studies by urine per 2 hours.
• Effect of diltiazem on the reduction in exercise-induced tachycardia and kinetic parameters of propranolol or atenolol.
• Phase I study of a clonidine patch, M-5041T.(2).
• Effects of .BETA.-blockers on carbohydrate metabolism and reaction of the cardiovascular system after insulin loading.
• Influence of Aging on the Oxidative and Conjugative Metabolism of Propranolol.
• Diuretic and uricosuric effects of traxanox sodium in healthy subjects: Comparison with hydrochlorothiazide by multiple-dose study.
• Pharmacokinetic and pharmacological effects of urapidil in healthy volunteers. Comparative study with prazosin.:Comparative Study with Prazosin
• The effect of the aging on pharmacokinetics and hypotensive response of Nitrendipine.
• Chronopharmacological study of furosemide in human subjects.
• Chronopharmacologic research of new thromboxane A2 receptor antagonist S-1452.
• タイトル無し
• タイトル無し
• Phase I study of a new Ca antagonist, SN305(lacidipine).
• Pharmacokinetics of beta-methyldigoxin.
• タイトル無し
• Comparison of clonidine patches and hypotensive effects on daytime and at night.
• Phase I study of therapeutic drug for hemicrania, Sumatriptan(SN-308).
• タイトル無し
• Pharmacokinetic and pharmacological properties of doxazosin mesilate in Japanese healthy adult volunteers.
• タイトル無し
• Effect of ageing on pharmacodynamics of Propranolol optical isomer.
• The effect of Furosemide on urinary excretion of Lomefloxacin.
• Clinical pharmacology of a new thromboxantin A2 receptor antagonist S-1452.
• Comparison between direct assay and separating assay of blood beta-methyldigoxin by fluorescent polarized immunoassay.
• タイトル無し
• タイトル無し
• タイトル無し

もっと見る 閉じる

スポンサーリンク