Diuretic and uricosuric effects of traxanox sodium in healthy subjects: Comparison with hydrochlorothiazide by multiple-dose study.
スポンサーリンク
概要
- 論文の詳細を見る
Diuretic and uricosuric effects of traxanox sodium (TRX, 180 mg three times daily for 8 days) were investigated by double blind, cross over comparison with hydro chlorothiazide (HCT, 25 mg twice daily for 8 days).<BR>Urine volume and urinary excretion of electrolytes increased after the administration of TRX. Asimilar trend was observed on HCT. The urinary excretion of uric acid increased and serum concentration of uric acid decreased on TRX. However, the urinary excreti on of uric acid decreased and serum concentration of uric acid in creased on HCT.<BR>Serum Na, K and Cl decreased, while serum Ca and PRA increased on HCT, while only serum Cl decreased on TRX. Neither drug induced any significant changes in blood pressure, pulse rate, body temperature or body weight.<BR>These results show that TRX has a uricosuric effect in humans.
- 一般社団法人 日本臨床薬理学会の論文
著者
関連論文
- 健常成人におけるバルプロ酸反復投与時の体内動態
- ヒスタミンH_2受容体遮断薬
- (4) 若年者高血圧における内分泌因子
- Dosage regimen for ranitidin in renal impairment. (2). Multiple oral dose studies.
- A compartment model for a sustained release preparation with zero-order release.
- Effect of diltiazem and cimetidine on the metabolism of Propranolol.
- Assessment of a simple method for acetylator phenotyping with caffeine.
- Polymorphous mode of caffeine metabolism in the Japanese poeple. On genotypes.
- Pharmacokinetics, pharmacodynamics, and safety of bevantolol, a new .BETA.1-selective .BETA.-adrenoceptor antagonist, in Japanese healthy volunteers.
- Clinical pharmacological studies on a new .BETA.1 selective .BETA.-blocker, bevantolol.
- Population pharmacokinetics of theophylline in patients with infantile bronchial asthma.
- Clinical pharmacology of ibopamine. (1). Safety and pharmacological actions after single and multiple oral doses in Japanese healthy subjects.
- Pharmacokinetics of beta-methyldigoxin.
- Clinical pharmacology of nitrendipine - Single- and multiple-dose study in Japanese healthy subjects.:Single- and Multiple-Dose Study in Japanese Healthy Subjects
- Pharmacokinetics of ketoprofen sustained-releasing preparation (RPY-001) in Japanese normal adult persons.
- Pharmacodynamic and pharmacological effects of nipradilol (K-351) in healthy volunteers. Comparison with propranolol.:Comparison with Propranolol
- Influence of beta-adrenergic blocking agent on the circadian rhythm of blood pressure in patients with essential hypertension.
- Pharmacodynamics and pharmacological action in essential hypertension patient of calcium antagonist CS-905.
- Clinical phase I studies of a new antiemetic drug, SN-307 (ondansetron).
- タイトル無し
- Pharmacokinetics of digoxin in patients with duchenne muscular dystrophy.
- Dosage regimen for ranitidine in renal impairment.
- Effects of prazosin and urapidil on the fingertip skin blood flow under cold exposure.
- 新しいヒスタミンH_2受容体遮断薬 Ranitidine の臨床薬理学的検討
- Clinic phase I study of migraine drug sumatriptan(SN-308).Single and repetitive subcutaneous injection test.
- タイトル無し
- Effect of cimetidine, diltiazem on oxidative metabolism of theophylline.
- Effect of diltiazem on the pharmacodynamics of Ca antagonist, MPC-1304.
- Influence of diltiazem on antipyrine and trimethadione.
- Effect of premedication term and premedication dose of diltiazem on pharmacokinetics of nifedipine.
- Effect of diltiazem on pharmacokinetics of theophylline.
- Pharmacodynamics and pharmacological actions of MPC-1304, a Ca antagonist, in healthy adults.
- Effects of angiotensin II converting enzyme inhibitor enarapril on autonomic nervous system.
- Pharmacodynamic and pharmacological effects of MPC-1304, a new calcium channel blocker, in healthy subjects. Results of multiple oral administration.:Results of Multiple Oral Administration
- Effect of Food and Gastric Acidity on the Pharmacokinetics of MPC-1304, a New Calcium Channel Blocker.
- Effects of MPC-1304 on blood flow of the finger tip.
- Pharmacokinetics and pharmacodynamic effects of sustained release formulation of urapidil (BKU) in healthy subjects. Results of repeated oral administration.:Results of Repeated Oral Administration
- Effect of ranitidine on urinary excretion by furosemide.
- タイトル無し
- Clinical pharmacology of a new antiplatelet drug, KBT-3022. Results of single administration in Japanese healthy adults.
- Clinical pharmacology of a new antiplatelet drug, KBT-3022. Studies on repeated administration in healthy adults.
- Effect of beta-blockers on circadian rhythm of blood pressure in patients with essential hypertension.
- Clinical pharmacology of ibopamine. (2). Pharmacokinetics after single and multiple oral administration in healthy Japanese subjects.
- Circadian variation in blood pressure in case of administration of various types of hypotensive drugs.
- Effects of ageing on liver metabolism of Propranolol.On oxidation, and conjugation reaction.
- タイトル無し
- タイトル無し
- Pharmacodynamic and pharmacological effects of MPC-1304, a new calcium channel blocker, in healthy subjects. Results of single oral administration.:Results of Single Oral Administration
- Pharmacokinetirs of diltiazem in patients with paroxysmal supraventricular tachycardia.
- Various types of caffeine metabolism in Japanese people. Studies by urine per 2 hours.
- Effect of diltiazem on the reduction in exercise-induced tachycardia and kinetic parameters of propranolol or atenolol.
- Phase I study of a clonidine patch, M-5041T.(2).
- Influence of Aging on the Oxidative and Conjugative Metabolism of Propranolol.
- Diuretic and uricosuric effects of traxanox sodium in healthy subjects: Comparison with hydrochlorothiazide by multiple-dose study.
- Pharmacokinetic and pharmacological effects of urapidil in healthy volunteers. Comparative study with prazosin.:Comparative Study with Prazosin
- The effect of the aging on pharmacokinetics and hypotensive response of Nitrendipine.
- Chronopharmacological study of furosemide in human subjects.
- Chronopharmacologic research of new thromboxane A2 receptor antagonist S-1452.
- タイトル無し
- タイトル無し
- タイトル無し
- Phase I study of a new Ca antagonist, SN305(lacidipine).
- Pharmacokinetics of beta-methyldigoxin.
- タイトル無し
- Comparison of clonidine patches and hypotensive effects on daytime and at night.
- Phase I study of therapeutic drug for hemicrania, Sumatriptan(SN-308).
- タイトル無し
- タイトル無し
- Pharmacokinetic and pharmacological properties of doxazosin mesilate in Japanese healthy adult volunteers.
- タイトル無し
- Effect of ageing on pharmacodynamics of Propranolol optical isomer.
- The effect of Furosemide on urinary excretion of Lomefloxacin.
- Clinical pharmacology of a new thromboxantin A2 receptor antagonist S-1452.
- Comparison between direct assay and separating assay of blood beta-methyldigoxin by fluorescent polarized immunoassay.
- タイトル無し
- タイトル無し
- タイトル無し