Chronopharmacological study of furosemide in human subjects.
スポンサーリンク
概要
- 論文の詳細を見る
The present study was undertaken to determine whether the effects of furosemidedepend on the administration time or not. After furosemide 20 mg or distilled water wasadministrated intravenously in 12 human volunteers at 9: 00 or at 21: 00, urine volumeand urinary excretion of sodium, choride, and furosemide were measured. There was nosignificant difference in urine volume and urinary excretion of sodium and chloridebetween when distilled water was given at 9: 00 and when given at 21: 00. Whenfurosemide was administrated at 21: 00, urine volume and urinary excretion of sodium, chloride, and furosemide during 60 min were significantly greater those administrated at9: 00. There was a marked correlation between the urinary output of furosemide and theurine volume, urinary sodium or chloride. These results suggest that the effects offurosemide vary with the administration time and the observed variations are mainlydependent on the amount of furosemide secreted to urine.
- 一般社団法人 日本臨床薬理学会の論文
著者
関連論文
- Metoprolol の薬物動態に及ぼす Mexiletine の影響
- 健常成人におけるバルプロ酸反復投与時の体内動態
- ヒスタミンH_2受容体遮断薬
- 平成5年度日本臨床薬理学会海外研修員報告書 : その3(研修完了報告書)
- Dosage regimen for ranitidin in renal impairment. (2). Multiple oral dose studies.
- A compartment model for a sustained release preparation with zero-order release.
- Effect of diltiazem and cimetidine on the metabolism of Propranolol.
- Assessment of a simple method for acetylator phenotyping with caffeine.
- Polymorphous mode of caffeine metabolism in the Japanese poeple. On genotypes.
- Pharmacokinetics, pharmacodynamics, and safety of bevantolol, a new .BETA.1-selective .BETA.-adrenoceptor antagonist, in Japanese healthy volunteers.
- Clinical pharmacological studies on a new .BETA.1 selective .BETA.-blocker, bevantolol.
- Population pharmacokinetics of theophylline in patients with infantile bronchial asthma.
- Clinical pharmacology of ibopamine. (1). Safety and pharmacological actions after single and multiple oral doses in Japanese healthy subjects.
- Pharmacokinetics of beta-methyldigoxin.
- Clinical pharmacology of nitrendipine - Single- and multiple-dose study in Japanese healthy subjects.:Single- and Multiple-Dose Study in Japanese Healthy Subjects
- Pharmacokinetics of ketoprofen sustained-releasing preparation (RPY-001) in Japanese normal adult persons.
- Pharmacodynamic and pharmacological effects of nipradilol (K-351) in healthy volunteers. Comparison with propranolol.:Comparison with Propranolol
- Influence of beta-adrenergic blocking agent on the circadian rhythm of blood pressure in patients with essential hypertension.
- Pharmacodynamics and pharmacological action in essential hypertension patient of calcium antagonist CS-905.
- Clinical phase I studies of a new antiemetic drug, SN-307 (ondansetron).
- タイトル無し
- Pharmacokinetics of digoxin in patients with duchenne muscular dystrophy.
- Dosage regimen for ranitidine in renal impairment.
- Effect of cimetidine, diltiazem on oxidative metabolism of theophylline.
- Effect of diltiazem on the pharmacodynamics of Ca antagonist, MPC-1304.
- Influence of diltiazem on antipyrine and trimethadione.
- Effect of premedication term and premedication dose of diltiazem on pharmacokinetics of nifedipine.
- Effect of diltiazem on pharmacokinetics of theophylline.
- Pharmacodynamics and pharmacological actions of MPC-1304, a Ca antagonist, in healthy adults.
- Effects of angiotensin II converting enzyme inhibitor enarapril on autonomic nervous system.
- Pharmacodynamic and pharmacological effects of MPC-1304, a new calcium channel blocker, in healthy subjects. Results of multiple oral administration.:Results of Multiple Oral Administration
- Effects of MPC-1304 on blood flow of the finger tip.
- Pharmacokinetics and pharmacodynamic effects of sustained release formulation of urapidil (BKU) in healthy subjects. Results of repeated oral administration.:Results of Repeated Oral Administration
- タイトル無し
- Clinical pharmacology of a new antiplatelet drug, KBT-3022. Results of single administration in Japanese healthy adults.
- Clinical pharmacology of a new antiplatelet drug, KBT-3022. Studies on repeated administration in healthy adults.
- Effect of beta-blockers on circadian rhythm of blood pressure in patients with essential hypertension.
- Clinical pharmacology of ibopamine. (2). Pharmacokinetics after single and multiple oral administration in healthy Japanese subjects.
- Circadian variation in blood pressure in case of administration of various types of hypotensive drugs.
- Effects of ageing on liver metabolism of Propranolol.On oxidation, and conjugation reaction.
- Effect of renal function on pharmacodynamics of beta-methyldigoxin.
- Pharmacodynamic and pharmacological effects of MPC-1304, a new calcium channel blocker, in healthy subjects. Results of single oral administration.:Results of Single Oral Administration
- Pharmacokinetirs of diltiazem in patients with paroxysmal supraventricular tachycardia.
- Various types of caffeine metabolism in Japanese people. Studies by urine per 2 hours.
- Effect of diltiazem on the reduction in exercise-induced tachycardia and kinetic parameters of propranolol or atenolol.
- Influence of Aging on the Oxidative and Conjugative Metabolism of Propranolol.
- Diuretic and uricosuric effects of traxanox sodium in healthy subjects: Comparison with hydrochlorothiazide by multiple-dose study.
- Pharmacokinetic and pharmacological effects of urapidil in healthy volunteers. Comparative study with prazosin.:Comparative Study with Prazosin
- The effect of the aging on pharmacokinetics and hypotensive response of Nitrendipine.
- Chronopharmacological study of furosemide in human subjects.
- Effects of ageing on the effect of Atenolol.Study of the density - effect relation using effect compartment model.
- Pharmacokinetics of beta-methyldigoxin.
- タイトル無し
- タイトル無し
- Pharmacokinetic and pharmacological properties of doxazosin mesilate in Japanese healthy adult volunteers.
- Combined effect of nifedipine and diltiazem on angina of effort.
- Effect of ageing on pharmacodynamics of Propranolol optical isomer.
- The effect of Furosemide on urinary excretion of Lomefloxacin.
- Comparison between direct assay and separating assay of blood beta-methyldigoxin by fluorescent polarized immunoassay.
- タイトル無し
- タイトル無し
- タイトル無し