Pharmacokinetic and pharmacological effects of urapidil in healthy volunteers. Comparative study with prazosin.:Comparative Study with Prazosin

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概要

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• BKU (a sustained release formulation of urapidil) 15, 30, and 60 mg and prazosin1 mg were orally administered consecutively at 1-week intervals to 6 healthy malevolunteers to compare their pharmacokinetic and pharmacological profiles.<BR>Both the time to maximum plasma concentration (t<SUB>max</SUB>) and the biological half-lifet(<SUB>1/2</SUB>) were longer for BKU than for prazosin. Supine blood pressure decreasedsignificantly after BKU, but not after prazosin. Supine pulse rate increased significantlyafter both drugs. A significant decrease of blood pressure was induced by change ofposition from supine to 50° tilt after both drugs, although no such alteration was inducedbefore drug administration. The exercise-induced elevation of systolic blood pressurewas diminished and the rise of heart rate was enhanced after both drugs.<BR>It is concluded that the pharmacokinetic profiles and mode of action of BKU aresimilar to prazosin except for longer t<SUB>max</SUB> and t<SUB>1/2</SUB> in BKU.

• 一般社団法人 日本臨床薬理学会の論文

著者

• 海老原 昭夫

  大分医科大学医学部臨床薬理学

• 近藤 和興

  自治医科大学臨床薬理

• 大橋 京一

  自治医科大学臨床薬理学教室

• 日野 尚子

  大分医科大学臨床薬理学教室

• 藤村 昭夫

  大分医科大学臨床薬理

• 日野 尚子

  大分医科大学臨床薬理

• 大橋 京一

  自治医科大学臨床薬理

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