Pharmacokinetics of digoxin in patients with duchenne muscular dystrophy.
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概要
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In order to elucidate the pharmacokinetic characteristics of digoxin in patients with Duchenne muscular dystrophy (DMD), digoxin was administered to nine patients with DMD and five healthy male volunteers.<BR>The two-compartment model was fitted to the digoxin plasma concentration-timecurve, using the nonlinear least-squares regression program APAS following a singleoral administration of digoxin 7μg/kg.<BR>The results were expressed as M± SE. The obtained pharmacokinetic parameterswere compared between DMD patients (n=9) and healthy volunteers (n=5).<BR>The volume of distribution (Vdss) was significantly lower in DMD patients (5.87±0.43<I>l</I>·kg<SUP>-1</SUP>) than in normal volunteers (8.28±0.84<I>l</I>·kg<SUP>-1</SUP>) (P<0.05). The half-life in βphase (t<SUB>1/2</SUB> β) was significantly shorter in DMD patients (16.93±2.17 hr) than innormal volunteers (33.73±5.20 hr) (P<0.05). The area under the curve (AUC<SUB>0</SUB>→<SUB>∞</SUB>) was significantly smaller in DMD patients (16.41±1.68ng·ml<SUP>-1</SUP>·hr) than in normalvolunteers (25.09±3.26ng·ml<SUP>-1</SUP>·hr) (P<0.05). The elimination rate constant (K<SUB>el</SUB>) was significantly larger in DMD patients (0.29±0.04hr<SUP>-1</SUP>) than in normal volunteers (0.15±0.02hr<SUP>-1</SUP>) (P<0.05).<BR>It is concluded that the dose of digoxin must be modified on the basis of these resultsin DMD patients.
- 一般社団法人 日本臨床薬理学会の論文
著者
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三吉野 産治
国立療養所西別府病院
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海老原 昭夫
大分医科大学医学部臨床薬理学
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三吉野 産治
国立療養所西別府
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海老原 昭夫
大分医科大学臨床薬理
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小池 勇一
大分医科大学 医学部臨床薬理
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小池 勇一
大分医科大学臨床薬理
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立石 正登
大分医科大学臨床薬理
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友枝 新一
国立療養所西別府病院
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木本 裕子
大分医科大学臨床薬理
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