Effect of Dosing Time on Trazodone Kinetics.

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Effects of dosing time of trazodone hydrochloride, (KB-831), a new antidepressant drug, on the pharmacokinetics were investigated by a cross-over method using 6 healthy male volunteers administered 50mg of the drug orally after breakfast or after supper. There were some effects of dosing time on the pharmacokinetics of trazodone hydrochloride, showing significantly higher Cmax and significantly larger AUC0-24hr in the group administered in the morning than in the evening. Mild drowsiness, dizziness, and dry mouth observed after the administration of trazodone hydrochloride were relatively stronger in the group administered in the morning than in the evening. From these results, it could be presumed that a single oral administration of the drug before sleep might be better for the reduction of the side effects of the drug.
一般社団法人日本臨床薬理学会の論文