抜歯後の炎症および疼痛に対する新非ステロイド性消炎鎮痛剤ONO-3144の効果 : 高・低投与量のONO-3144とメフェナム酸およびプラシーボとを用いた二重盲検法

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The effect of a new non-steroidal anti-inflammatory agent, ONO-3144, with an action mechanism different from those of known agents on postoperative inflammation following minor oral surgery was evaluated by a double-blind controlled clinical trial using mefenamic acid and inactive placebo. The results we as follows:<BR>1) Among the total 320 cases in the present study, the following were subjected to analysis: 304 cases for analgesic effect and oveall safety rating (excluding 16 exclusion cases), 282 cases for anti-inflammatory effect (excluding 22 drop-out and 16 exclusion cases) and 289 cases for utility rating (including 7 drop-out cases where drug administration was discontinued due to side effects or insufficient effect). There was good inter-group equivalency in terms of patient background and adequate random allocation was confirmed.<BR>2) In the 0-H group (ONO-3144, high dose), 44% efficacy in analgesic effect, 71% efficacy in anti-inflammatory effect and 65% utility taking into accout of side effects were observed, providing significantly better efficacy and utility than in any of the 0-L group (ONO-3144, low dose), M group (mefenamic acid 600mg/day) and P group (inactive placebo).<BR>3) Incidence of side effects was 13% in the O-H group, 10% in O-L group, 3% in M group and 9% in P group, without any significant intergroup difference. Gastrointestinal symptoms were the mainside effects of ONO-3144, but none were severe.<BR>4) Based on the foregoing results, it is concluded that ONO-3144 is worthy of use as a postoperative, anti-inflammatory agent following oral surgerys.

抜歯後の炎症および疼痛に対する新非ステロイド性消炎鎮痛剤ONO-3144の効果 : 高・低投与量のONO-3144とメフェナム酸およびプラシーボとを用いた二重盲検法

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