Dehydrooligopeptides. II. The synthesis of dehydrodehydrodipeptides by direct coupling and base-catalyzed .BETA.-elimination.
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概要
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The direct coupling between N-protected α-dehydroamino acid (<B>1</B>) and N-free α-dehydroamino acid ester (<B>2</B>) by the acid-chloride method was carried out to give several dehydrodehydrodipeptides (<B>7</B>). Furthermore, the two kinds of dehydrodipeptides with a hydroxyl group, obtained by the coupling of <B>1</B> with a serine or threonine ester, and that of N-protected serine or threonine with <B>2</B>, followed by mesylation and subsequent base-catalyzed β-elimination gave a number of <B>7</B> substances in good yields. The configurational structures of <B>7</B> obtained by both direct condensation and elimination were found to have (<I>Z</I>,<I>Z</I>)-geometry.
- 公益社団法人 日本化学会の論文
著者
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Shin Chung-gi
Laboratory Of Oraganic Chemistry Faculty Of Engineering Kanagawa University
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Yonezawa Yasuchika
Laboratory Of Oraganic Chemistry Faculty Of Engineering Kanagawa University
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Yoshimura Juji
Laboratorium für Organische Chemie Technische Hochschule Tokyo
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Takahashi Masatoshi
Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa University
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Shin Chung-gi
Laboratory of Chemistry for Natural Products, Faculty of Science, Tokyo Institute of Technology
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